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N-trans-Sinapoyltyramine

Name: N-trans-Sinapoyltyramine
Brand: TargetMol
SKU: TN4618
Price: 248 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN4618Cas No. 200125-11-7

N-trans-Sinapoyltyramine exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 9.77 ± 1.25 Μm.

N-trans-Sinapoyltyramine

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Purity: 99.73%

Catalog No. TN4618Cas No. 200125-11-7

N-trans-Sinapoyltyramine exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 9.77 ± 1.25 Μm.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$248	In Stock	In Stock
5 mg	$620	In Stock	In Stock
10 mg	$882	In Stock	In Stock
25 mg	$1,330	In Stock	In Stock
50 mg	$1,780	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$630	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.73%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

N-trans-Sinapoyltyramine AI Summary

N-trans-Sinapoyltyramine is a multi-faceted chemical entity exhibiting various biological activities. It demonstrates growth inhibition against HepG2, VA13, and WI38 cells with an IC50 value greater than 20.0 µg/mL. In terms of antiproliferative efficacy, it shows limited activity against a range of human cell lines such as A549, MCF7, ZR-75-1, SK-BR-3, MDA-MB-231, DU145, KB, and KBVIN, with IC50 values exceeding 40,000.0 nM. Specific tests on human MDA-MB-231 and MDA-MB-468 cells expressing c-MET reveal IC50 values of 72,800.0 nM and 80,200.0 nM, respectively, for antiproliferative activity, and greater than 50,000.0 nM for antimigratory activity in MDA-MB-231 cells. Its antimycobacterial activity against Mycobacterium tuberculosis H37Rv shows a MIC greater than 100.0 µg/mL, indicating limited effectiveness at this concentration. Additionally, it exhibits antimicrobial properties against Streptococcus pyogenes and Staphylococcus aureus with a MIC of 62.5 µg/mL. N-trans-Sinapoyltyramine also possesses antineuroinflammatory activity, inhibiting LPS-induced NO production in mouse BV2 cells with an IC50 greater than 50,000.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

N-trans-Sinapoyltyramine exhibited strong and selective cytotoxicity on the HeLa human cancer cell line with IC50 values of 9.77 ± 1.25 Μm.

Chemical Properties

Molecular Weight	343.37
Formula	C₁₉H₂₁NO₅
Cas No.	200125-11-7
Smiles	C(=C/C(NCCC1=CC=C(O)C=C1)=O)\C2=CC(OC)=C(O)C(OC)=C2
Relative Density.	1.248 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (160.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9123 mL	14.5616 mL	29.1231 mL	145.6155 mL
5 mM	0.5825 mL	2.9123 mL	5.8246 mL	29.1231 mL
10 mM	0.2912 mL	1.4562 mL	2.9123 mL	14.5616 mL
20 mM	0.1456 mL	0.7281 mL	1.4562 mL	7.2808 mL
50 mM	0.0582 mL	0.2912 mL	0.5825 mL	2.9123 mL
100 mM	0.0291 mL	0.1456 mL	0.2912 mL	1.4562 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc