IL-18BP Protein, Human, Recombinant

Name: IL-18BP Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPS-00068
Rating: 4.5 (1 reviews)

(Synonyms: Tadekinig-alfa, IL18BP) Copy Product Info

Synonyms: Tadekinig-alfa, IL18BP

Catalog No. TMPS-00068 Copy Product Info

IL-18BP Protein, Human, Recombinant is expressed in CHO Cells. The accession number is O95998.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$54	7-10 days	7-10 days
10 µg	$85	7-10 days	7-10 days
20 µg	$113	7-10 days	7-10 days
50 µg	$170	7-10 days	7-10 days
100 µg	$297	7-10 days	7-10 days
200 µg	$562	7-10 days	7-10 days
500 µg	$1,260	7-10 days	7-10 days
1 mg	$2,330	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Bioactivity

Bioactivity	ED 50 < 30.0 ng /ml, measured in a bioassay using KG-1 cells in the presence of 50.0 ng/ml Human IL-18.
Description	IL-18BP Protein, Human, Recombinant is expressed in CHO Cells. The accession number is O95998.
Species	Human
Expression System	CHO Cells
Tag	Tag Free
Accession Number	O95998
Construction	Thr31-Gly194
Protein Purity	> 95% as determined by SDS-PAGE; > 95% as determined by HPLC
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	Tadekinig-alfa, IL18BP
Research Background	Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP.

Chemical Properties

Molecular Weight

42~44 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.