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IL-18BP Protein, Human, Recombinant
Catalog No. TMPS-00068 Copy Product Info
IL-18BP Protein, Human, Recombinant is expressed in CHO Cells. The accession number is O95998.
IL-18BP Protein, Human, Recombinant
Catalog No. TMPS-00068
Copy Product InfoIL-18BP Protein, Human, Recombinant is expressed in CHO Cells. The accession number is O95998.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 5 μg | $54 | 7-10 days | 7-10 days | |
| 10 μg | $85 | 7-10 days | 7-10 days | |
| 20 μg | $113 | 7-10 days | 7-10 days | |
| 50 μg | $170 | 7-10 days | 7-10 days | |
| 100 μg | $297 | 7-10 days | 7-10 days | |
| 200 μg | $562 | 7-10 days | 7-10 days | |
| 500 μg | $1,260 | 7-10 days | 7-10 days | |
| 1 mg | $2,330 | 7-10 days | 7-10 days |
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In stock · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Information
| Biological Activity | ED 50 < 30.0 ng /ml, measured in a bioassay using KG-1 cells in the presence of 50.0 ng/ml Human IL-18. |
| Description | IL-18BP Protein, Human, Recombinant is expressed in CHO Cells. The accession number is O95998. |
| Species | Human |
| Expression System | CHO Cells |
| Tag | Tag Free |
| Accession Number | O95998 |
| Synonyms | Tadekinig-alfa,IL18BP |
| Construction | Thr31-Gly194 |
| Protein Purity | > 95% as determined by SDS-PAGE; > 95% as determined by HPLC |
| Molecular Weight | 42~44 kDa (Reducing conditions) |
| Endotoxin | < 0.2 EU/μg of protein as determined by the LAL method. |
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. |
| Reconstitution | Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing. |
| Stability & Storage | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
| Shipping | In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice. |
| Research Background | Interleukin-18 binding protein, also known as IL-18BP and tadekinig-alfa, is a secreted glycoprotein that contains an Ig-like C2-type domain. It is expressed in heart, lung, placenta and spleen. IL-18BP functions as an inhibitor of the proinflammatory cytokine IL-18. It binds to IL-18, prevents the binding of IL-18 to its receptor, and thus blocks IL-18-induced IFN-gamma production. The complete Ig domain has been shown to mediate the binding and neutralizing properties. IFN-gamma is able to upregulate the expression of IL-18BP, indicating that IL-18 activity is regulated by a feedback mechanism through IL-18BP. |
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