Powder: -20°C for 3 years | In solvent: -80°C for 1 year
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 129.00 | |
2 mg | In stock | $ 234.00 | |
5 mg | In stock | $ 352.00 | |
10 mg | In stock | $ 525.00 | |
25 mg | In stock | $ 851.00 |
Description | E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When administered to mice, this compound suppress responses to challenge doses of cytidine-phosphate-guanidine (CpG)-containing DNA, which stimulates TLR9. |
Molecular Weight | 449.59 |
Formula | C27H35N3O3 |
CAS No. | 1219925-73-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9 mg/mL (20 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
E6446 1219925-73-1 Immunology/Inflammation TLR E-6446 E 6446 inhibitor inhibit