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L-NBDNJ is a sugar mimic and an antivirulence agent. It disrupts the expression of proteins that regulate the assembly and organization of the host cell cytoskeleton. In cystic fibrosis (CF) lung disease infection models, L-NBDNJ exhibits both anti-inflammatory and anti-infective properties.
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| 10 mg | Inquiry | Backorder | Backorder | |
| 50 mg | Inquiry | Backorder | Backorder |
| Description | L-NBDNJ is a sugar mimic and an antivirulence agent. It disrupts the expression of proteins that regulate the assembly and organization of the host cell cytoskeleton. In cystic fibrosis (CF) lung disease infection models, L-NBDNJ exhibits both anti-inflammatory and anti-infective properties. |
| In vitro | L-NBDNJ is a sugar mimic and an antivirulence agent. It disrupts the expression of proteins that regulate host cell cytoskeletal assembly and organization. L-NBDNJ must interfere with the metabolic pathways involved in host cell cytoskeletal assembly and organization, downregulating key virulence factors of Pseudomonas aeruginosa involved in host response and affecting the adhesion of pathogens to human cells. |
| In vivo | L-NBDNJ (10-100 mg/kg; oral gavage; daily for 6 days) demonstrates anti-inflammatory and anti-infective properties in mice. |
| Formula | C10H21NO4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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