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Sodium citrate monobasic

Name: Sodium citrate monobasic
Brand: TargetMol
SKU: TSH-00076
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TSH-00076Cas No. 18996-35-5

Alias Citric acid monosodium salt

Sodium citrate monobasic (Citric acid monosodium salt) is a biochemical reagent serving as a preservative, emulsifier, chelating agent, and buffer. Monobasic sodium citrate induces apoptosis in HaCaT cells and causes cell cycle arrest at the G2/M and S phases. It also induces hepatic oxidative damage by reducing antioxidant enzyme activity.

Sodium citrate monobasic

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Catalog No. TSH-00076Alias Citric acid monosodium saltCas No. 18996-35-5

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 g	$29	-	In Stock

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Appearance:Solid

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	Sodium citrate monobasic (Citric acid monosodium salt) is a biochemical reagent serving as a preservative, emulsifier, chelating agent, and buffer. Monobasic sodium citrate induces apoptosis in HaCaT cells and causes cell cycle arrest at the G2/M and S phases. It also induces hepatic oxidative damage by reducing antioxidant enzyme activity.
In vitro	Sodium citrate monobasic (0–12.5 mM; 24 h) exhibited dose-dependent antiproliferative activity [1]. Sodium citrate monobasic (12.5 mM; 48/72 h) induced apoptosis, cell cycle arrest at G2/M and S phases, increased expression of FAS, BAX, BID, AIF, EndoG, cytochrome C, PARP, GADD153, GRP78, and Caspase-3, -8, -9 expression, while decreasing BCL-2 and BCL-Xl expression [1].
In vivo	Sodium citrate monobasic (120, 240, and 480 mg/kg; intraperitoneal injection) significantly reduced GSH-Px activity in mouse liver, induced elevated MDA (malondialdehyde) levels, and induced apoptosis in mouse hepatocytes in a dose-dependent manner by increasing caspase-3 activity [2].
Synonyms	Citric acid monosodium salt

Chemical Properties

Molecular Weight	214.11
Formula	C₆H₇NaO₇
Cas No.	18996-35-5
Smiles	O=C(CC(C(O)=O)(CC(O)=O)O)[O-].[Na+]

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year

Solubility Information

H2O: 40.00 mg/mL (186.82 mM), Sonication is recommended.

DMSO: 1.50 mg/mL (7.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	4.6705 mL	23.3525 mL	46.7050 mL	233.5248 mL
5 mM	0.9341 mL	4.6705 mL	9.3410 mL	46.7050 mL

H2O

	1mg	5mg	10mg	50mg
10 mM	0.4670 mL	2.3352 mL	4.6705 mL	23.3525 mL
20 mM	0.2335 mL	1.1676 mL	2.3352 mL	11.6762 mL
50 mM	0.0934 mL	0.4670 mL	0.9341 mL	4.6705 mL
100 mM	0.0467 mL	0.2335 mL	0.4670 mL	2.3352 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc