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PRO-905
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Catalog No. T208298Cas No. 2762209-68-5
Alias MK-905
Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395.
PRO-905
Copy Product Info😃Good
Catalog No. T208298Alias MK-905Cas No. 2762209-68-5
Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395. |
| In vitro | Pro-905 (10 µM, 120 h) in combination with JHU395 (1 µM, 120 h) suppresses the proliferation of JH-2-002 cells and the incorporation of guanine into newly synthesized DNA and RNA. This combination also inhibits colony formation of human MPNST cells sNF96.2 and JH-2-002. Additionally, Pro-905 (10 µM, 6 h) reduces the binding of purine-dependent 3H-hypoxanthine to DNA and RNA in sNF96.2 cells. |
| In vivo | Pro-905 administered at 20 mg/kg via intraperitoneal injection, five days a week for four weeks, reduced tumor growth in NSG mice bearing human MPNST PDX JH-2-031. In a B6 flank MPNST mouse model, the combination of Pro-905 at 10 mg/kg (intraperitoneal injection, five days a week) and JHU395 at 1.2 mg/kg (oral administration) inhibited tumor nucleotide metabolism and suppressed MPNST proliferation. |
| Synonyms | MK-905 |
| Molecular Weight | 568.54 |
| Formula | C22H29N6O8PS |
| Cas No. | 2762209-68-5 |
| Smiles | S=C1C2=C(N(C=N2)[C@@H]3O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OC(C)C)=O)C)=O)[C@@H](O)[C@H]3O)NC(N)=N1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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