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PRO-905
🥰Excellent
Catalog No. T208298Cas No. 2762209-68-5
Alias MK-905
Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395.
PRO-905
🥰Excellent
Catalog No. T208298Alias MK-905Cas No. 2762209-68-5
Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Pro-905 is a phosphonate peptide with antitumor activity. It delivers the active nucleotide antimetabolite thioinosine monophosphate (TGMP) to tumors. Pro-905 effectively inhibits the binding of purine residue substrates to nucleic acids, thereby suppressing colony formation of human malignant peripheral nerve sheath tumor (MPNST) cells. It prevents purine residues from incorporating into nucleic acids, hindering cell growth. Additionally, Pro-905 inhibits the growth of MPNST and enhances the antitumor effect of JHU395. |
| In vitro | Pro-905 (10 µM, 120 h) in combination with JHU395 (1 µM, 120 h) suppresses the proliferation of JH-2-002 cells and the incorporation of guanine into newly synthesized DNA and RNA. This combination also inhibits colony formation of human MPNST cells sNF96.2 and JH-2-002. Additionally, Pro-905 (10 µM, 6 h) reduces the binding of purine-dependent 3H-hypoxanthine to DNA and RNA in sNF96.2 cells. |
| In vivo | Pro-905 administered at 20 mg/kg via intraperitoneal injection, five days a week for four weeks, reduced tumor growth in NSG mice bearing human MPNST PDX JH-2-031. In a B6 flank MPNST mouse model, the combination of Pro-905 at 10 mg/kg (intraperitoneal injection, five days a week) and JHU395 at 1.2 mg/kg (oral administration) inhibited tumor nucleotide metabolism and suppressed MPNST proliferation. |
| Synonyms | MK-905 |
| Molecular Weight | 568.54 |
| Formula | C22H29N6O8PS |
| Cas No. | 2762209-68-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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