SARS PLpro/papain-like protease Protein (His)

Name: SARS PLpro/papain-like protease Protein (His)
Brand: TargetMol
SKU: TMPK-01384
Rating: 4.5 (1 reviews)

(Synonyms: Replicase polyprotein 1a, pp1a, PL-PRO, Plpro, PL2-PRO, Papain-like Protease, nsp1) Copy Product Info

Synonyms: Replicase polyprotein 1a, pp1a, PL-PRO, Plpro, PL2-PRO, Papain-like Protease, nsp1

Catalog No. TMPK-01384 Copy Product Info

The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 36.91 kDa and the accession number is AAX16193.1.

SARS PLpro/papain-like protease Protein (His)

Pack Size	Price	USA Stock	Global Stock
10 µg	$92	7-10 days	7-10 days
20 µg	$148	7-10 days	7-10 days
50 µg	$289	7-10 days	7-10 days
100 µg	$487	7-10 days	7-10 days
200 µg	$883	7-10 days	7-10 days
500 µg	$1,950	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. SARS PLpro/papain-like protease Protein (His) is expressed in E. coli expression system with C-His tag. The predicted molecular weight is 36.91 kDa and the accession number is AAX16193.1.
Species	SARS
Expression System	E. coli
Tag	C-His
Accession Number	AAX16193.1
Construction	Glu1541-Tyr1859
Protein Purity	> 95% as determined by Tris-Bis PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as 0.22 μm filtered solution in 50 mM Tris, 0.1% Tween, 150 mM NaCl (pH 9.0).
Synonyms	Replicase polyprotein 1a, pp1a, PL-PRO, Plpro, PL2-PRO, Papain-like Protease, nsp1
Research Background	The coronaviral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro), are attractive antiviral drug targets because they are essential for coronaviral replication. Although the primary function of PLpro and 3CLpro are to process the viral polyprotein in a coordinated manner, PLpro has the additional function of stripping ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses.

Chemical Properties

Molecular Weight

36.91 kDa (predicted) same as Tris-Bis PAGE result.

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots.