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5-Nonadecylresorcinol

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Catalog No. TN3129Cas No. 35176-46-6

5-Nonadecylresorcinol is a natural alkylresorcinol isolated from wheat bran. This product exhibits significant anti-degranulation activity in the RBL-2H3 cell model, effectively inhibiting DNP-BSA-induced release of β-hexosaminidase. It shows no cytotoxicity at experimental concentrations and serves as a pharmacological tool for researching natural anti-allergic agents and their mechanisms in mast-cell-like cells.

5-Nonadecylresorcinol

5-Nonadecylresorcinol

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Catalog No. TN3129Cas No. 35176-46-6
5-Nonadecylresorcinol is a natural alkylresorcinol isolated from wheat bran. This product exhibits significant anti-degranulation activity in the RBL-2H3 cell model, effectively inhibiting DNP-BSA-induced release of β-hexosaminidase. It shows no cytotoxicity at experimental concentrations and serves as a pharmacological tool for researching natural anti-allergic agents and their mechanisms in mast-cell-like cells.
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2 mg$29-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
5-Nonadecylresorcinol is a natural alkylresorcinol isolated from wheat bran. This product exhibits significant anti-degranulation activity in the RBL-2H3 cell model, effectively inhibiting DNP-BSA-induced release of β-hexosaminidase. It shows no cytotoxicity at experimental concentrations and serves as a pharmacological tool for researching natural anti-allergic agents and their mechanisms in mast-cell-like cells.
In vitro
In cell-based assays, 5-Nonadecylresorcinol demonstrates dose-dependent inhibition of antigen-stimulated degranulation in RBL-2H3 cells; the compound significantly reduces the secretion of β-hexosaminidase, a key marker of allergic response, while maintaining high cell viability as measured by MTT assays [1].
Chemical Properties
Molecular Weight376.62
FormulaC25H44O2
Cas No.35176-46-6
SmilesOC=1C=C(O)C=C(C1)CCCCCCCCCCCCCCCCCCC
Relative Density.0.942g/cm3
Storage & Solubility Information
Storagestore at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (212.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6552 mL13.2760 mL26.5520 mL132.7598 mL
5 mM0.5310 mL2.6552 mL5.3104 mL26.5520 mL
10 mM0.2655 mL1.3276 mL2.6552 mL13.2760 mL
20 mM0.1328 mL0.6638 mL1.3276 mL6.6380 mL
50 mM0.0531 mL0.2655 mL0.5310 mL2.6552 mL
100 mM0.0266 mL0.1328 mL0.2655 mL1.3276 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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