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Artobiloxanthone
🥰Excellent
Catalog No. TN11214
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). It inhibits the Akt/mTOR and STAT3 pathways, thereby suppressing the proliferation of SAS and T.Tn cells with IC50 values of 11 and 22 μM, respectively, as well as cancer cell migration. Artobiloxanthone induces cell apoptosis in OSCC by activating caspase3/9 and causes cell cycle arrest at the S phase.
Artobiloxanthone
Artobiloxanthone
🥰Excellent
Catalog No. TN11214
Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). It inhibits the Akt/mTOR and STAT3 pathways, thereby suppressing the proliferation of SAS and T.Tn cells with IC50 values of 11 and 22 μM, respectively, as well as cancer cell migration. Artobiloxanthone induces cell apoptosis in OSCC by activating caspase3/9 and causes cell cycle arrest at the S phase.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Artobiloxanthone (Compound AA3) exhibits antitumor activity, particularly against oral squamous cell carcinoma (OSCC). It inhibits the Akt/mTOR and STAT3 pathways, thereby suppressing the proliferation of SAS and T.Tn cells with IC50 values of 11 and 22 μM, respectively, as well as cancer cell migration. Artobiloxanthone induces cell apoptosis in OSCC by activating caspase3/9 and causes cell cycle arrest at the S phase. |
| Formula | C25H22O7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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