β-1,3-Glucan is a major constituent of all characterized fungal cell walls, comprising 30% to 80% of wall mass, and β-1,3-Glucan exists as a branched polymer in the cell wall, with branches connected via β-1,6 linkages, enabling investigation into fungal structural biology, cell wall assembly, immunomodulation, and antifungal therapeutic targeting.

β-1,3-Glucan (0.5-5 mg/mL, 3 days) significantly promotes the proliferation of L-929 fibroblast cells [2].

Adding 0.09% β-1,3-Glucan to feed and administering it orally twice daily for 8 consecutive weeks can effectively promote the growth and development of Larimichthys crocea, enhance its innate immune function, and improve its resistance to Vibrio harveyi infection [1].
Administering β-1,3-Glucan either orally (20 mg/kg/day for 14 consecutive days) or via subcutaneous injection (2 mg/kg/day for 3 consecutive days) can promote blood pressure recovery in a rat endotoxemia model, alleviate liver and kidney function damage in the model animals, and regulate cytokine levels in vivo [3].
For a rat sepsis model induced by cecal ligation and puncture (CLP), intramuscular injection of 2 mg/kg β-1,3-Glucan immediately after surgery and again 4 hours post-surgery can significantly improve the survival rate of the model rats, alleviate acute lung injury symptoms, and inhibit the release of pro-inflammatory cytokines [4].
Administering 150 mg/kg β-1,3-glucan orally once daily for 7 consecutive days to adult male Balb/c mice can reverse the immunosuppressive state induced by Aflatoxin B1, increase the proportion of lymphocyte subsets, and elevate the expression levels of multiple cytokines [6].