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VUF 8430 dihydrobromide

Name: VUF 8430 dihydrobromide
Brand: TargetMol
SKU: T23520
Rating: 4.5 (1 reviews)

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Catalog No. T23520Cas No. 100130-32-3

Alias VUF-8430 dihydrobromide, VUF8430 dihydrobromide

VUF 8430 dihydrobromide is a potent and selective histamine H4 receptor agonist with a Ki value of 31.6 nM and an EC50 of 50 nM, commonly used in immunology and inflammation research to investigate H4 receptor–mediated signaling, immune cell chemotaxis, cytokine release, and the role of histamine in allergic and inflammatory responses.

VUF 8430 dihydrobromide

😃Good

Catalog No. T23520Alias VUF-8430 dihydrobromide, VUF8430 dihydrobromideCas No. 100130-32-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$133	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	VUF 8430 dihydrobromide is a potent and selective histamine H4 receptor agonist with a Ki value of 31.6 nM and an EC50 of 50 nM, commonly used in immunology and inflammation research to investigate H4 receptor–mediated signaling, immune cell chemotaxis, cytokine release, and the role of histamine in allergic and inflammatory responses.
In vitro	In HEK293 cells expressing the human Histamine H4 receptor (H4R), VUF 8430 dihydrobromide functioned as a full agonist with a Ki of 31 nM. It inhibited forskolin-induced cAMP accumulation and triggered calcium mobilization and MAPK phosphorylation. Furthermore, the agonist induced the chemotaxis of eosinophils and mast cells in immune cell recruitment assays [1].
In vivo	In mouse models, subcutaneous injection of VUF 8430 dihydrobromide induces scratching behavior, a physiological marker of the itch response. This behavior is inhibited by selective H4 receptor antagonists, such as JNJ 7777120. These observations indicate that H4R signaling mediates histamine-induced pruritus through a pathway independent of H1 receptors [1].
Synonyms	VUF-8430 dihydrobromide, VUF8430 dihydrobromide

Chemical Properties

Molecular Weight	323.05
Formula	C₄H₁₃Br₂N₅S
Cas No.	100130-32-3
Smiles	N=C(N)SCCNC(N)=N.Br.Br
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 100 mg/mL (309.55 mM), Sonication is recommended.

DMSO: <32.31 mg/mL, Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	3.0955 mL	15.4775 mL	30.9550 mL	154.7748 mL
5 mM	0.6191 mL	3.0955 mL	6.1910 mL	30.9550 mL
10 mM	0.3095 mL	1.5477 mL	3.0955 mL	15.4775 mL
20 mM	0.1548 mL	0.7739 mL	1.5477 mL	7.7387 mL
50 mM	0.0619 mL	0.3095 mL	0.6191 mL	3.0955 mL
100 mM	0.0310 mL	0.1548 mL	0.3095 mL	1.5477 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc