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Hexaconazole

Name: Hexaconazole
Brand: TargetMol
SKU: T5966
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5966Cas No. 79983-71-4

Alias (-)-Hexaconazol

Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.

Hexaconazole

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Purity: 97.77%

Catalog No. T5966Alias (-)-HexaconazolCas No. 79983-71-4

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$35	In Stock	In Stock
500 mg	$52	In Stock	In Stock
1 g	$64	-	In Stock
5 g	$127	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:97.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Hexaconazole ((-)-Hexaconazol) is a broad-spectrum triazole fungicide that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death.
In vitro	Hexaconazole is fungicidal against the powdery mildews B. graminis and S. cucurbitae on cucumber plants in a concentration-dependent manner and is curative against powdery mildew on barley plants when used at a concentration of 6.7 mg/L[1].It also inhibits growth of R. bataticola and S. rolfsii (ED50s = 6.35 and 1.27 mg/L, respectively)[2].
Cell Research	The medium was poured into a set of two petriplates under aseptic conditions in a laminar flow hood.?When the medium in the plates was solidified, a mycelial disc of 0.5 cm diameter of freshly grown test fungi taken from periphery was inoculated upside down at the center of the plates.?These treated petri dishes were incubated at 28℃ until fungal growth in the control plates was almost complete.?Hexaconazole used as commercial fungicide and acetone served as control.?All the compounds were tested in triplicates.?The mycelia growth of fungi (mm) in both treated (T) and control (C) petri plates was measured diametrically in three different directions and growth inhibition (I) and corrected inhibition (IC) were calculated by using Abbott s formula[2]
Synonyms	(-)-Hexaconazol

Chemical Properties

Molecular Weight	314.21
Formula	C₁₄H₁₇Cl₂N₃O
Cas No.	79983-71-4
Smiles	CCCCC(O)(Cn1cncn1)c1ccc(Cl)cc1Cl
Relative Density.	1.29. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (175.04 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1826 mL	15.9129 mL	31.8258 mL	159.1292 mL
5 mM	0.6365 mL	3.1826 mL	6.3652 mL	31.8258 mL
10 mM	0.3183 mL	1.5913 mL	3.1826 mL	15.9129 mL
20 mM	0.1591 mL	0.7956 mL	1.5913 mL	7.9565 mL
50 mM	0.0637 mL	0.3183 mL	0.6365 mL	3.1826 mL
100 mM	0.0318 mL	0.1591 mL	0.3183 mL	1.5913 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc