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NVP-DFV890

Name: NVP-DFV890
Brand: TargetMol
SKU: T88849
Price: 392 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: NLRP3 antagonist 2) Copy Product Info

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Synonyms: NLRP3 antagonist 2

Catalog No. T88849 Copy Product Info

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NVP-DFV890 is an orally active and selective NLRP3 inflammasome inhibitor that directly binds to and inhibits NLRP3 activation, thereby blocking the maturation and release of IL-1β and IL-18 and reducing pyroptotic cell death. NVP-DFV890 has shown immunomodulatory effects in viral infection and inflammatory models and is primarily investigated in COVID-19 and acute respiratory distress syndrome to attenuate excessive inflammatory responses.

Cas No. 2271394-34-2

Pack Size	Price	USA Stock	Global Stock
1 mg	$392	-	In Stock
5 mg	$952	-	In Stock
10 mg	$1,290	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	NVP-DFV890 is an orally active and selective NLRP3 inflammasome inhibitor that directly binds to and inhibits NLRP3 activation, thereby blocking the maturation and release of IL-1β and IL-18 and reducing pyroptotic cell death. NVP-DFV890 has shown immunomodulatory effects in viral infection and inflammatory models and is primarily investigated in COVID-19 and acute respiratory distress syndrome to attenuate excessive inflammatory responses.
In vivo	NVP-DFV890 inhibits NLRP3-mediated secretion of IL-1β and IL-18, as well as pyroptotic cell death, in mouse models of inflammatory mechanisms [1].
Synonyms	NLRP3 antagonist 2

Chemical Properties

Molecular Weight	420.55
Formula	C₁₉H₂₄N₄O₃S₂
Cas No.	2271394-34-2
Smiles	N(C(NS(=N)(=O)C=1SC(C(C)(C)O)=NC1)=O)C2=C3C(=CC4=C2CCC4)CCC3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (190.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3778 mL	11.8892 mL	23.7784 mL	118.8919 mL
5 mM	0.4756 mL	2.3778 mL	4.7557 mL	23.7784 mL
10 mM	0.2378 mL	1.1889 mL	2.3778 mL	11.8892 mL
20 mM	0.1189 mL	0.5945 mL	1.1889 mL	5.9446 mL
50 mM	0.0476 mL	0.2378 mL	0.4756 mL	2.3778 mL
100 mM	0.0238 mL	0.1189 mL	0.2378 mL	1.1889 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Related Tags: NVP-DFV890 chemical structure | NVP-DFV890 in vivo | NVP-DFV890 formula | NVP-DFV890 molecular weight