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(R)-C12-200 (Synonyms: KB-R12)

Catalog No. TCL-02361 Copy Product Info
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(R)-C12-200, an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200, is utilized in forming lipid nanoparticles (LNPs) for delivering mRNA in vivo. When administered intravenously, LNPs containing (R)-C12-200 with mRNA encoding Cre recombinase result in a smaller increase in the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice compared to LNPs with (S)-C12-200. Additionally, LNPs with (R)-C12-200 carrying mRNA for purine nucleoside phosphorylase (PNP), an E. coli enzyme that transforms fludarabine phosphate into the cytotoxic agent 2-fluoroadenine, prompt intratumoral PNP expression and diminish tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when fludarabine phosphate is co-administered.

(R)-C12-200

Copy Product Info
🥰Excellent
Catalog No. TCL-02361
Synonyms KB-R12

(R)-C12-200, an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200, is utilized in forming lipid nanoparticles (LNPs) for delivering mRNA in vivo. When administered intravenously, LNPs containing (R)-C12-200 with mRNA encoding Cre recombinase result in a smaller increase in the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice compared to LNPs with (S)-C12-200. Additionally, LNPs with (R)-C12-200 carrying mRNA for purine nucleoside phosphorylase (PNP), an E. coli enzyme that transforms fludarabine phosphate into the cytotoxic agent 2-fluoroadenine, prompt intratumoral PNP expression and diminish tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when fludarabine phosphate is co-administered.


(R)-C12-200
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Product Introduction

Bioactivity
Description
(R)-C12-200, an ionizable cationic lipid (pKa = 7.25) and isomer of C12-200, is utilized in forming lipid nanoparticles (LNPs) for delivering mRNA in vivo. When administered intravenously, LNPs containing (R)-C12-200 with mRNA encoding Cre recombinase result in a smaller increase in the percentage of tdTomato+ hepatocytes, endothelial cells, and Kupffer cells in the liver of Ai14 mice compared to LNPs with (S)-C12-200. Additionally, LNPs with (R)-C12-200 carrying mRNA for purine nucleoside phosphorylase (PNP), an E. coli enzyme that transforms fludarabine phosphate into the cytotoxic agent 2-fluoroadenine, prompt intratumoral PNP expression and diminish tumor volume in a FaDu head and neck squamous cell carcinoma (HNSCC) mouse xenograft model when fludarabine phosphate is co-administered.
SynonymsKB-R12
Chemical Properties
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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