store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be used to study idiopathic pulmonary hypertension.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 120.00 | |
10 mg | In stock | $ 150.00 | |
25 mg | In stock | $ 198.00 | |
50 mg | In stock | $ 297.00 | |
100 mg | In stock | $ 455.00 |
Description | MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be used to study idiopathic pulmonary hypertension. |
In vitro | In a concentration-dependent manner, MIF098 (0-10 μM, 48 h) inhibits mPASMC cell proliferation and migration by blocking the migration inhibitory factor (MIF) pathway[1].By inhibiting the TGFβ1/Smad2/3 pathway, MIF098 reduces collagen synthesis and pulmonary artery fibrosis [1]. |
In vivo | Administered through intraperitoneal injection at a dose of 40 mg/kg once a day for 4 weeks, MIF098 attenuates the progression of hypoxia-induced pulmonary arterial hypertension in C57BL/6J mice [1]. |
Molecular Weight | 255.27 |
Formula | C15H13NO3 |
CAS No. | 1208448-95-6 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 80 mg/mL (313.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MIF098 1208448-95-6 Others inhibitor inhibit