Dehydrocorydaline (hydroxyl)

Name: Dehydrocorydaline (hydroxyl)
Brand: TargetMol
SKU: TN11627
Rating: 4.5 (1 reviews)

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Catalog No. TN11627

Alias 13-Methylpalmatine (hydroxyl)

Dehydrocorydaline hydroxyl (13-Methylpalmatine) is an alkaloid that modulates the expression of Bax and Bcl-2 proteins, activates caspase-7 and caspase-8, and inactivates PARP. It enhances the activation of p38 MAPK and exhibits anti-inflammatory and anticancer properties. Additionally, it shows potent antimalarial activity with low cytotoxicity (cell viability > 90%) against the P. falciparum 3D7 strain (IC50 = 38 nM).

Dehydrocorydaline (hydroxyl)

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Catalog No. TN11627Alias 13-Methylpalmatine (hydroxyl)

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Product Introduction

Bioactivity

Description	Dehydrocorydaline hydroxyl (13-Methylpalmatine) is an alkaloid that modulates the expression of Bax and Bcl-2 proteins, activates caspase-7 and caspase-8, and inactivates PARP. It enhances the activation of p38 MAPK and exhibits anti-inflammatory and anticancer properties. Additionally, it shows potent antimalarial activity with low cytotoxicity (cell viability > 90%) against the P. falciparum 3D7 strain (IC50 = 38 nM).
In vitro	Dehydrocorydaline hydroxy (0-200 μM) significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. After 24 hours of treatment with 200 μM Dehydrocorydaline hydroxy, cell viability decreases by approximately 40%. This compound also enhances the expression of Bax protein while reducing Bcl-2 protein expression, and induces the activation of caspase-7 and -8 along with PARP cleavage, without affecting caspase-9.
In vivo	Dehydrocorydaline hydroxy exhibits low acute toxicity, with an oral LD50 in mice of approximately 277.5±19.0 mg/kg body weight, and 21.1±1.4 mg/kg for intraperitoneal injection.
Synonyms	13-Methylpalmatine (hydroxyl)

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc