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3,4-DAA

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Catalog No. T22506Cas No. 2117759-07-4

3,4-DAA has anti-inflammatory activity, ameliorates acute hepatic allograft injury, and alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.3,4-DAA inhibits EOC20 cell-inducible nitric oxide synthase (iNOS) induced by IFN-γ and lipopolysaccharide.

3,4-DAA

3,4-DAA

😃Good
Catalog No. T22506Cas No. 2117759-07-4
3,4-DAA has anti-inflammatory activity, ameliorates acute hepatic allograft injury, and alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.3,4-DAA inhibits EOC20 cell-inducible nitric oxide synthase (iNOS) induced by IFN-γ and lipopolysaccharide.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 mg$3454-6 weeks4-6 weeks
10 mg$5894-6 weeks4-6 weeks
50 mg$2,0504-6 weeks4-6 weeks
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
3,4-DAA has anti-inflammatory activity, ameliorates acute hepatic allograft injury, and alleviates severe acute pancreatitis by inhibiting intestinal barrier dysfunction and NF-κB activation.3,4-DAA inhibits EOC20 cell-inducible nitric oxide synthase (iNOS) induced by IFN-γ and lipopolysaccharide.
In vitro
3,4-DAA can alleviate the severity of colitis by inhibiting the response of Th1 cells, promoting the expression of Th2 cytokines, and inducing the expression of CD4(+)CD25(+) T cells[1].
In vivo
3,4-DAA is an orally active synthetic derivative of the tryptophan metabolite anthranilic acid, which can reverse paralysis in mice with experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS)[1].
Chemical Properties
Molecular Weight343.33
FormulaC18H17NO6
Cas No.2117759-07-4
SmilesO=C(O)C=1C=CC=C(O)C1NC(=O)C=CC2=CC=C(OC)C(OC)=C2
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 5 mg/mL (14.56 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9126 mL14.5632 mL29.1265 mL145.6325 mL
5 mM0.5825 mL2.9126 mL5.8253 mL29.1265 mL
10 mM0.2913 mL1.4563 mL2.9126 mL14.5632 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

iNOS3,4-DAA3,4DAA3,4 DAA
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