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20-carboxy Arachidonic Acid

Name: 20-carboxy Arachidonic Acid
Brand: TargetMol
SKU: T36232
Rating: 4.5 (1 reviews)

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Catalog No. T36232Cas No. 79551-84-1

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

20-carboxy Arachidonic Acid

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Catalog No. T36232Cas No. 79551-84-1

Pack Size	Price	USA Warehouse	Global Warehouse
25 μg	$812	35 days	35 days
50 μg	$1,530	35 days	35 days
100 μg	$2,830	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	334.456
Formula	C₂₀H₃₀O₄
Cas No.	79551-84-1
Smiles	OC(=O)CCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

0.1 M Na2CO3: 1.5 mg/mL (4.48 mM), Sonication is recommended.

DMF: 100 mg/mL (298.99 mM), Sonication is recommended.

Ethanol: 100 mg/mL (298.99 mM), Sonication is recommended.

DMSO: 100 mg/mL (298.99 mM), Sonication is recommended.

Solution Preparation Table

0.1 M Na2CO3/DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9899 mL	14.9496 mL	29.8993 mL	149.4965 mL

DMF/Ethanol/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5980 mL	2.9899 mL	5.9799 mL	29.8993 mL
10 mM	0.2990 mL	1.4950 mL	2.9899 mL	14.9496 mL
20 mM	0.1495 mL	0.7475 mL	1.4950 mL	7.4748 mL
50 mM	0.0598 mL	0.2990 mL	0.5980 mL	2.9899 mL
100 mM	0.0299 mL	0.1495 mL	0.2990 mL	1.4950 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc