Powder: -20°C for 3 years | In solvent: -80°C for 1 year
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 μg | 35 days | $ 560.00 | |
50 μg | 35 days | $ 1,060.00 | |
100 μg | 35 days | $ 1,960.00 |
Description | 20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 μM) and PPARγ (Kd = 1.7 ± 0.5 μM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system. |
Molecular Weight | 334.456 |
Formula | C20H30O4 |
CAS No. | 79551-84-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
0.1 M Na2CO3: 1.5 mg/mL
DMF: 100 mg/mL
Ethanol: 100 mg/mL
DMSO: 100 mg/mL
You can also refer to dose conversion for different animals. More
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20-carboxy Arachidonic Acid 79551-84-1 20carboxy Arachidonic Acid 20 carboxy Arachidonic Acid inhibitor inhibit