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Lithium acetate dihydrate

Name: Lithium acetate dihydrate
Brand: TargetMol
SKU: TXB-00788
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TXB-00788Cas No. 6108-17-4

Lithium acetate dihydrate is a commonly used source of lithium. In molecular biology research, it is a key component of the "lithium acetate/single-stranded carrier DNA/polyethylene glycol (LiAc/SS-DNA/PEG)" method for yeast transformation. This product significantly enhances the efficiency of exogenous DNA (e.g., plasmids) entry into cells by altering the permeability of the yeast cell wall and plasma membrane. It serves as an important pharmacological and biochemical reagent for synthesizing other lithium compounds and conducting fungal genetic engineering research.

Lithium acetate dihydrate

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Purity: 99.98%

Catalog No. TXB-00788Cas No. 6108-17-4

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Appearance:Solid

Color:Transparent

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Lithium acetate dihydrate is a commonly used source of lithium. In molecular biology research, it is a key component of the "lithium acetate/single-stranded carrier DNA/polyethylene glycol (LiAc/SS-DNA/PEG)" method for yeast transformation. This product significantly enhances the efficiency of exogenous DNA (e.g., plasmids) entry into cells by altering the permeability of the yeast cell wall and plasma membrane. It serves as an important pharmacological and biochemical reagent for synthesizing other lithium compounds and conducting fungal genetic engineering research.
In vitro	In biochemical and molecular protocols, Lithium acetate dihydrate acts as a chemical competence-inducing agent that prepares yeast cells for DNA uptake; when combined with PEG and carrier DNA, it optimizes the interaction between the negatively charged DNA and the yeast cell surface, resulting in efficient delivery of genetic material into the cytoplasm with high cell viability [1].
In vivo	In yeast models such as S. cerevisiae, 0.1 M Lithium acetate dihydrate used in the LiAc/SS-DNA/PEG protocol significantly increases transformation efficiency. Lithium ions facilitate the passage of high-molecular-weight DNA through the cell wall and plasma membrane, ensuring genomic integration or plasmid maintenance for genetic screening [1].

Chemical Properties

Molecular Weight	102.02
Formula	C₂H₇LiO₄
Cas No.	6108-17-4
Smiles	O=C(C)[O-].[Li+].O.O

Storage & Solubility Information

Storage

keep away from moisture | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (784.16 mM), Sonication is recommended.

H2O: 80 mg/mL (784.16 mM), Sonication is recommended.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	9.8020 mL	49.0100 mL	98.0200 mL	490.1000 mL
5 mM	1.9604 mL	9.8020 mL	19.6040 mL	98.0200 mL
10 mM	0.9802 mL	4.9010 mL	9.8020 mL	49.0100 mL
20 mM	0.4901 mL	2.4505 mL	4.9010 mL	24.5050 mL
50 mM	0.1960 mL	0.9802 mL	1.9604 mL	9.8020 mL
100 mM	0.0980 mL	0.4901 mL	0.9802 mL	4.9010 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc