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Neoprzewaquinone A

Name: Neoprzewaquinone A
Brand: TargetMol
SKU: TN1985
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TN1985Cas No. 630057-39-5

Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 and blocking the ROCK2/STAT3 pathway.

Neoprzewaquinone A

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Catalog No. TN1985Cas No. 630057-39-5

Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 and blocking the ROCK2/STAT3 pathway.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$123	-	In Stock
2 mg	Preferential	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Appearance:Solid

Color:Red to Black

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Product Introduction

Bioactivity

Description	Neoprzewaquinone A (NEO), an active ingredient of S. miltiorrhiza, inhibits breast cancer cell migration and promotes smooth muscle relaxation by targeting PIM1 and blocking the ROCK2/STAT3 pathway.
In vitro	The active ingredient Neoprzewaquinone A (NEO) in crocetin selectively inhibits PIM1,a phenomenon observed at nanomolar concentrations. NEO effectively inhibits the PIM1 kinase and significantly suppresses the growth, migration, and epithelial-mesenchymal transition (EMT) of the triple-negative breast cancer cell line MDA-MB-231 in vitro [1].

Chemical Properties

Molecular Weight	556.6
Formula	C₃₆H₂₈O₆
Cas No.	630057-39-5
Smiles	Cc1coc-2c1C(=O)C(=O)c1c-2ccc2c1CCCC(=C)c1ccc3-c4occ(C)c4C(=O)C(=O)c3c1CC\C=C2/C
Relative Density.	1.36 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 4.5 mg/mL (8.08 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7966 mL	8.9831 mL	17.9662 mL	89.8311 mL
5 mM	0.3593 mL	1.7966 mL	3.5932 mL	17.9662 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc