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Hardwickiic acid

Name: Hardwickiic acid
Brand: TargetMol
SKU: TN4183
Rating: 4.5 (1 reviews)

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Catalog No. TN4183Cas No. 1782-65-6

Alias (-)-Hardwikiic acid

Hardwickiic acid ((-)-Hardwickiic acid) is a natural compound derived from Pulicaria gnaphalodes with anti-injury receptor properties. It blocks tetrodotoxin-sensitive voltage-dependent sodium channels and exhibits anti-inflammatory and insecticidal activity.

Hardwickiic acid

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Catalog No. TN4183Alias (-)-Hardwikiic acidCas No. 1782-65-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 mg	$1,480	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$1,968	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Hardwickiic acid ((-)-Hardwickiic acid) is a natural compound derived from Pulicaria gnaphalodes with anti-injury receptor properties. It blocks tetrodotoxin-sensitive voltage-dependent sodium channels and exhibits anti-inflammatory and insecticidal activity.
Targets&IC50	J774 cells:＜100 µM
In vitro	Hardwickiic acid was isolated from the oleoresins of Copaifera spp. Hardwickiic acid did not show cytotoxicity in normal cell lines, nor did it show significant changes in viability of tumoral line cells. Hardwickiic acid (92.7% ± 4.9%) at 100 mM inhibited nitric oxide production in macrophages activated by lipopolysaccharide. In this assay, Hardwickiic acid did not inhibit tumor necrosis factor-α production.[1]
Synonyms	(-)-Hardwikiic acid

Chemical Properties

Molecular Weight	316.43
Formula	C₂₀H₂₈O₃
Cas No.	1782-65-6
Smiles	[H][C@]12CCC=C(C(O)=O)[C@]1(C)CC[C@@H](C)[C@]2(C)CCc1ccoc1
Relative Density.	1.068g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc