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Lith-O-Asp

Name: Lith-O-Asp
Brand: TargetMol
SKU: T11858
Rating: 4.5 (1 reviews)

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Catalog No. T11858Cas No. 881179-02-8

Lith-O-Asp is a sialytransferase (ST) inhibitor with IC50 values ranging from 12 to 37 μM.

Lith-O-Asp

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Catalog No. T11858Cas No. 881179-02-8

Lith-O-Asp is a sialytransferase (ST) inhibitor with IC50 values ranging from 12 to 37 μM.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$523	6-8 weeks	6-8 weeks
25 mg	$1,520	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:White

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Product Introduction

Bioactivity

Description	Lith-O-Asp is a sialytransferase (ST) inhibitor with IC50 values ranging from 12 to 37 μM.
Targets&IC50	ST:12-37 μM
In vitro	The results indicate that Lith-O-Asp reduces the activity of both a-2,3- and a-2,6-sialyltransferases, consequently inhibiting the transfer of sialic acids to target glycoproteins[1]. Despite showing no significant growth inhibition effect on various cancer cell lines at doses of 10, 30, and 60 μM, in vitro assays reveal Lith-O-Asp's capability to suppress the activities of ST3Gal I, ST3Gal III, and ST6GalI, with IC50 values ranging from 12 to 37 μM. Furthermore, flow cytometry analysis demonstrates a marked decrease in the expression of cell surface a-2,3- and a-2,6-sialylated antigens.
In vivo	In lung tissues of mice treated with DMSO and observed using the IVIS in vivo imaging system, a significant presence of secondary metastatic cancer cells was noted 26 days post-fat pad inoculation. Conversely, mice treated with Lith-O-Asp exhibited a reduction in lung metastases, with only 3 of 8 mice showing any metastasis compared to all DMSO-treated mice. The average number of tumor nodules per mouse in the DMSO group was 11±9, while in the Lith-O-Asp group, it was significantly lower at 2±4 nodules. Additionally, 4T1-Luc illumination signals, indicating tumor presence, were markedly stronger in the DMSO control group than in the Lith-O-Asp-treated group on days 7 and 9[1].

Chemical Properties

Molecular Weight	491.66
Formula	C₂₈H₄₅NO₆
Cas No.	881179-02-8
Smiles	[H][C@@]1(CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)[C@@H](N)CC(O)=O)[C@H](C)CCC(O)=O
Relative Density.	1.19 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 106 mg/mL (215.6 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0339 mL	10.1696 mL	20.3393 mL	101.6963 mL
5 mM	0.4068 mL	2.0339 mL	4.0679 mL	20.3393 mL
10 mM	0.2034 mL	1.0170 mL	2.0339 mL	10.1696 mL
20 mM	0.1017 mL	0.5085 mL	1.0170 mL	5.0848 mL
50 mM	0.0407 mL	0.2034 mL	0.4068 mL	2.0339 mL
100 mM	0.0203 mL	0.1017 mL	0.2034 mL	1.0170 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc