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Methoxychlor

🥰Excellent
Catalog No. T5627Cas No. 72-43-5

Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca2 homeostasis and cell viability in different cell models.

Methoxychlor

Methoxychlor

🥰Excellent
Purity: 99.75%
Catalog No. T5627Cas No. 72-43-5
Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca2 homeostasis and cell viability in different cell models.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$29In Stock-
50 mgPreferentialIn Stock-
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.75%
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Product Introduction

Bioactivity
Description
Methoxychlor, an organochlorine pesticide, is thought to be an endocrine disrupter that affects Ca2 homeostasis and cell viability in different cell models.
In vitro
In HA59T cells, methoxychlor induced a [Ca2?]i rise by inducing Ca2? entry via protein kinase C-sensitive Ca2?-permeable channels, without causing Ca2? release from stores. Methoxychlor also induced apoptosis that was independent of [Ca2?]i rises.
Cell Research
Fura-2, a Ca2?-sensitive fluorescent dye, was applied to measure [Ca2?]i. Methoxychlor at concentrations of 0.1-1 μM caused a [Ca2?]i rise in a concentration-dependent manner. Removal of external Ca2? abolished methoxychlor's effect. Methoxychlor-induced Ca2? influx was confirmed by Mn2?-induced quench of fura-2 fluorescence. Methoxychlor-induced Ca2? entry was inhibited by nifedipine, econazole, SK&F96365, and protein kinase C modulators. Methoxychlor killed cells at concentrations of 10-130 μM in a concentration-dependent fashion. Chelation of cytosolic Ca2? with 1,2-bis(2-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid/AM (BAPTA/AM) did not prevent methoxychlor's cytotoxicity. Methoxychlor (10 and 50 μM) induced apoptosis concentration-dependently as determined by using Annexin V/propidium iodide staining
Chemical Properties
Molecular Weight345.65
FormulaC16H15Cl3O2
Cas No.72-43-5
SmilesCOc1ccc(cc1)C(c1ccc(OC)cc1)C(Cl)(Cl)Cl
Relative Density.1.4 g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 22.5 mg/mL (65.09 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8931 mL14.4655 mL28.9310 mL144.6550 mL
5 mM0.5786 mL2.8931 mL5.7862 mL28.9310 mL
10 mM0.2893 mL1.4465 mL2.8931 mL14.4655 mL
20 mM0.1447 mL0.7233 mL1.4465 mL7.2327 mL
50 mM0.0579 mL0.2893 mL0.5786 mL2.8931 mL

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Keywords

Methoxychlor
Related Tags: buy Methoxychlor | purchase Methoxychlor | Methoxychlor cost | order Methoxychlor | Methoxychlor chemical structure | Methoxychlor in vitro | Methoxychlor formula | Methoxychlor molecular weight
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