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SP94
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Catalog No. TP3858Cas No. 1158983-49-3
SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. It selectively binds to various hepatocellular carcinoma cell lines in vitro. In mouse models of hepatocellular carcinoma, SP94 inhibits tumor growth by promoting tumor cell apoptosis (apoptosis) and reducing tumor angiogenesis. SP94 can serve as a specific probe for imaging hepatocellular carcinoma and is applicable in hepatocellular carcinoma research.
SP94
😃Good
Catalog No. TP3858Cas No. 1158983-49-3
SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. It selectively binds to various hepatocellular carcinoma cell lines in vitro. In mouse models of hepatocellular carcinoma, SP94 inhibits tumor growth by promoting tumor cell apoptosis (apoptosis) and reducing tumor angiogenesis. SP94 can serve as a specific probe for imaging hepatocellular carcinoma and is applicable in hepatocellular carcinoma research.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. It selectively binds to various hepatocellular carcinoma cell lines in vitro. In mouse models of hepatocellular carcinoma, SP94 inhibits tumor growth by promoting tumor cell apoptosis (apoptosis) and reducing tumor angiogenesis. SP94 can serve as a specific probe for imaging hepatocellular carcinoma and is applicable in hepatocellular carcinoma research. |
| In vitro | SP94 (40 nM HspG41C-SM(PEG)n-SP94, 12/23 peptide/cage, 24 hours) selectively binds to HepG2 and Huh-7 cells, while showing no binding affinity to HeLa and RLN-8 cells. |
| In vivo | In the Mahlavu cell xenograft mouse model, SP94 (100 µg + PC94, single dose/1 mg/kg (SP94-LD), administered intravenously once or twice weekly for 2-4 consecutive weeks) inhibits the recovery of phage particles from tumor tissue, suppresses tumor growth by enhancing apoptosis in tumor cells, and reduces tumor angiogenesis. |
| Molecular Weight | 1337.60 |
| Formula | C65H104N14O16 |
| Cas No. | 1158983-49-3 |
| Smiles | C([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@H](CO)N)=O)=O)CO)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)=O)[C@@H](C)O)=O)CCC1)[C@H](CC)C)=O)CC(C)C)(=O)N4[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)CCC4 |
| Sequence | Ser-Phe-Ser-Ile-Ile-His-Thr-Pro-Ile-Leu-Pro-Leu |
| Sequence Short | SFSIIHTPILPL |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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