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GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated
(Synonyms: Growth arrest-specific protein 6, GAS-6, AXLLG, AXL receptor tyrosine kinase ligand) Copy Product InfoSynonyms: Growth arrest-specific protein 6, GAS-6, AXLLG, AXL receptor tyrosine kinase ligand
Catalog No. TMPJ-00365 Copy Product Info
Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. It also can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry.
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $213 | 7-10 days | 7-10 days | |
| 20 µg | $355 | 7-10 days | 7-10 days | |
| 50 µg | $625 | 7-10 days | 7-10 days | |
| 100 µg | $963 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Bioactivity | Loaded Biotinylated Human GAS6-Avi-His on SA Biosensor, can bind Human AXL-Fc with an affinity constant of 1.02 pM as determined in BLI assay. (Regularly tested) |
| Description | Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. It also can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. |
| Species | Human |
| Expression System | HEK293 Cells |
| Tag | C-Avi-6xHis |
| Accession Number | Q14393 |
| Amino Acid | Ala31-Ala678 |
| Construction | Ala31-Ala678 |
| Protein Purity | Greater than 95% as determined by reducing SDS-PAGE. (QC verified) |
| Endotoxin | < 0.1 ng/µg (1 EU/µg) as determined by LAL test. |
| Formulation | Supplied as a 0.2 μm filtered solution of 20 mM PB, 8% Sucrose, 0.05% Tween 80, pH 7.0. |
| Synonyms | Growth arrest-specific protein 6, GAS-6, AXLLG, AXL receptor tyrosine kinase ligand |
| Research Background | Human Growth arrest-specific protein 6 (GAS6) is ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. It also can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry. |
| Molecular Weight | 80-90 KDa (reducing condition) |
| Shipping | Proteins are shipped with blue ice. |
| Storage | Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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Related Tags: GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated chemical structure | GAS6 Protein, Human, Recombinant (Avi & His), Biotinylated molecular weight
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