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Carboxy-pyridostatin

Name: Carboxy-pyridostatin
Brand: TargetMol
SKU: T30745
Rating: 4.5 (1 reviews)

Catalog No. T30745 Copy Product Info

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Carboxy-pyridostatin is a carboxyl-modified derivative of pyridostatin, a classic G-quadruplex ligand, capable of selectively binding to and stabilizing G-quadruplex structures, thereby influencing the DNA conformation in regions related to telomeres and gene regulation. Carboxy-pyridostatin exhibits high molecular specificity for RNA on DNA G4s and can downregulate the ATF-5 protein. Carboxy-pyridostatin inhibits cell proliferation and impedes the formation of stress granules (SGs).

Carboxy-pyridostatin

Copy Product Info

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Catalog No. T30745

Cas No. 1417638-60-8

Pack Size	Price	USA Stock	Global Stock	Quantity
5 mg	$1,365	Inquiry	Inquiry
25 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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Custom-made molecule. TargetMol’s expert synthesis team delivers cost-effective solutions. Contact us for inquiries. Committed to serving you.However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Appearance:Solid

Color:White

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COA

Product Introduction

Bioactivity

Description	Carboxy-pyridostatin is a carboxyl-modified derivative of pyridostatin, a classic G-quadruplex ligand, capable of selectively binding to and stabilizing G-quadruplex structures, thereby influencing the DNA conformation in regions related to telomeres and gene regulation. Carboxy-pyridostatin exhibits high molecular specificity for RNA on DNA G4s and can downregulate the ATF-5 protein. Carboxy-pyridostatin inhibits cell proliferation and impedes the formation of stress granules (SGs).
In vitro	Carboxy-pyridostatin(10 μM； 24 h) can prevent the formation of stress granules (SG) in U2OS cells [3].
In vivo	Carboxy-pyridostatin (10 mg/kg； Intraperitoneal injection; Once every 12 hours; Injected three times) significantly reduced the number of cells expressing PCNA in SVZ of adult mice, and increased the number of cells expressing OLIG2 in corpus callosum of mice [1].

Chemical Properties

Molecular Weight	706.71
Formula	C₃₅H₃₄N₁₀O₇
Cas No.	1417638-60-8
Smiles	O=C(O)CCN1N=NC(=C1)COC=2C=C(N=C(C2)C(=O)NC=3N=C4C=CC=CC4=C(OCCN)C3)C(=O)NC=5N=C6C=CC=CC6=C(OCCN)C5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 1 mg/mL (1.42 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4150 mL	7.0750 mL	14.1501 mL	70.7504 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc