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4,7-DIHYDROXYCOUMARIN

Name: 4,7-DIHYDROXYCOUMARIN
Brand: TargetMol
SKU: T4137
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T4137 Copy Product Info

Purity: 99.2%

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4,7-DIHYDROXYCOUMARIN is a naturally occurring coumarin derivative found in a variety of plants, including parsley and chamomile. It has been found to inhibit the activity of several enzymes, including cytochrome P450, cyclooxygenase and lipoxygenase. It can also bind to DNA, regulate gene expression, and inhibit cell cycle progression. It can also induce apoptosis in tumor cells and reduce inflammation.

4,7-DIHYDROXYCOUMARIN

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Catalog No. T4137

Cas No. 1983-81-9

Pack Size	Price	USA Stock	Global Stock	Quantity
100 mg	$32	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.2%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

4,7-DIHYDROXYCOUMARIN AI Summary

4,7-DIHYDROXYCOUMARIN exhibits multifunctional bioactivities, notably including inhibition of HIV-1 integrase with IC50 values of 300,000 nM and 325,000 nM for 3'-processing and DNA integration, respectively. It also inhibits Human Jumonji Domain Containing 2E (JMJD2E) with an IC50 of 28,183.8 nM, MLL CXXC domain - DNA interaction with 89,125.1 nM, Aldehyde Dehydrogenase 1 (ALDH1A1) with 25,118.9 nM, and RanGTP-induced Rango - Importin beta complex dissociation with 4,109.5 nM. Its potency extends to delayed death inhibitors of the malarial parasite plastid (928.5 nM) and as a substrate for Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) at 39,810.7 nM. Additionally, it acts as an agonist for gsp with a potency of 891.3 nM and inhibits human tyrosyl-DNA phosphodiesterase 1 (TDP1) in cells in the absence and presence of CPT with potencies of 23,109.3 nM and 16,360.1 nM, respectively. 4,7-DIHYDROXYCOUMARIN also inhibits TDP-43 (14,125.4 nM) and Alpha-syn (22,387.2 nM) and has inhibitory effects on alpha-glucosidase (IC50 of 38,850.0 nM) and beta-glucosidase (36.7% reduction at 400 μM), although it does not inhibit Aspergillus oryzae Beta-galactosidase at the same concentration. Furthermore, it significantly alters the secondary structure of alpha-glucosidase, impacting the alpha-helix, beta-sheet, beta-turn, and random content..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	178.14
Formula	C₉H₆O₄
Cas No.	1983-81-9
Smiles	Oc1ccc2c(O)cc(=O)oc2c1
Relative Density.	1.612g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (336.81 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.6136 mL	28.0678 mL	56.1356 mL	280.6781 mL
5 mM	1.1227 mL	5.6136 mL	11.2271 mL	56.1356 mL
10 mM	0.5614 mL	2.8068 mL	5.6136 mL	28.0678 mL
20 mM	0.2807 mL	1.4034 mL	2.8068 mL	14.0339 mL
50 mM	0.1123 mL	0.5614 mL	1.1227 mL	5.6136 mL
100 mM	0.0561 mL	0.2807 mL	0.5614 mL	2.8068 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc