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Arg-Gly-Asp-Cys TFA

Name: Arg-Gly-Asp-Cys TFA
Brand: TargetMol
SKU: T39655
Rating: 4.5 (1 reviews)

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Arg-Gly-Asp-Cys TFA, as a recognition motif for fibronectin and cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding.

Cas No. 2171504-22-4

Pack Size	Price	USA Stock	Global Stock	Quantity
2 mg	$83	5 days	5 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description

Arg-Gly-Asp-Cys TFA, as a recognition motif for fibronectin and cell adhesion molecules, inhibits platelet aggregation and fibrinogen binding.

In vitro

Method: Human dermal fibroblasts (HDF) were treated with Arg-Gly-Asp-Cys-functionalized chitosan (0.25, 0.5, 1 mg/mL) for 2, 4, and 7 days, and cell viability was assessed using the WST-1 assay.
Result: After 7 days of treatment with Arg-Gly-Asp-Cys-functionalized chitosan at concentrations of 0.25 and 0.5 mg/mL, HDF viability was significantly higher than that of the control group (p ≤ 0.0001 and p ≤ 0.01), with cell viability exceeding 140%, indicating that the Arg-Gly-Asp-Cys peptide promotes fibroblast proliferation [1].

Chemical Properties

Molecular Weight	677.53
Formula	C₁₉H₂₉F₆N₇O₁₁S
Cas No.	2171504-22-4
Smiles	OC(C(F)(F)F)=O.OC([C@H](CS)NC([C@H](CC(O)=O)NC(CNC([C@@H](N)CCCNC(N)=N)=O)=O)=O)=O.OC(C(F)(F)F)=O
Relative Density.	no data available
Sequence	Arg-Gly-Asp-Cys
Sequence Short	RGDC

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 200 mg/mL (295.19 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	1.4759 mL	7.3797 mL	14.7595 mL	73.7975 mL
5 mM	0.2952 mL	1.4759 mL	2.9519 mL	14.7595 mL
10 mM	0.1476 mL	0.7380 mL	1.4759 mL	7.3797 mL
20 mM	0.0738 mL	0.3690 mL	0.7380 mL	3.6899 mL
50 mM	0.0295 mL	0.1476 mL	0.2952 mL	1.4759 mL
100 mM	0.0148 mL	0.0738 mL	0.1476 mL	0.7380 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Arg-Gly-Asp-Cys TFAArgGlyAspCys TFAArg Gly Asp Cys TFA

Related Tags: Arg-Gly-Asp-Cys TFA chemical structure | Arg-Gly-Asp-Cys TFA in vitro | Arg-Gly-Asp-Cys TFA formula | Arg-Gly-Asp-Cys TFA molecular weight