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Apoptosis inducer 40
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Catalog No. T212509Cas No. 83800-90-2
Apoptosis inducer40 is an apoptosis (apoptosis) inducer that exhibits potent cytotoxic effects on Jurkat and NB4 cells, with IC50 values of 4.5 μM and 3.6 μM, respectively. It promotes apoptosis and arrests the cell cycle, making it applicable for cancer research, particularly in the study of acute myeloid leukemia (AML).
Apoptosis inducer 40
😃Good
Catalog No. T212509Cas No. 83800-90-2
Apoptosis inducer40 is an apoptosis (apoptosis) inducer that exhibits potent cytotoxic effects on Jurkat and NB4 cells, with IC50 values of 4.5 μM and 3.6 μM, respectively. It promotes apoptosis and arrests the cell cycle, making it applicable for cancer research, particularly in the study of acute myeloid leukemia (AML).
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Apoptosis inducer40 is an apoptosis (apoptosis) inducer that exhibits potent cytotoxic effects on Jurkat and NB4 cells, with IC50 values of 4.5 μM and 3.6 μM, respectively. It promotes apoptosis and arrests the cell cycle, making it applicable for cancer research, particularly in the study of acute myeloid leukemia (AML). |
| In vitro | Apoptosis inducer 40 (Compound 17) at concentrations of 0.8-50 μM over 24-72 hours reduces the viability of Jurkat and NB4 cells in a time-dependent manner. At 0.6-10 μM for 48 hours, it induces apoptosis in these cells. Additionally, at 3.6-4.5 μM from 0-48 hours, it causes G0/G1 phase arrest in Jurkat cells and S phase arrest in NB4 cells. |
| Molecular Weight | 291.13 |
| Formula | C14H8Cl2N2O |
| Cas No. | 83800-90-2 |
| Smiles | O=C1N=C(NC=2C=CC=CC12)C=3C=CC=C(Cl)C3Cl |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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