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Synonyms: CD246, Anaplastic lymphoma kinase, ALK tyrosine kinase receptor


| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 µg | $76 | 7-10 days | 7-10 days | |
| 20 µg | $122 | 7-10 days | 7-10 days | |
| 50 µg | $236 | 7-10 days | 7-10 days | |
| 100 µg | $393 | 7-10 days | 7-10 days | |
| 200 µg | $712 | 7-10 days | 7-10 days | |
| 500 µg | $1,570 | 7-10 days | 7-10 days |
| Bioactivity | Activity has not been tested. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first. |
| Description | Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. |
| Species | Mouse |
| Expression System | HEK293 Cells |
| Tag | C-hFc |
| Accession Number | P97793 |
| Construction | Ser19-Cys692 |
| Protein Purity | > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC |
| Endotoxin | < 1.0 EU/μg of the protein as determined by the LAL method. |
| Formulation | Supplied as 0.22 μm filtered solution in PBS, 10% Glycerol (pH 7.4). |
| Synonyms | CD246, Anaplastic lymphoma kinase, ALK tyrosine kinase receptor |
| Research Background | Anaplastic lymphoma kinase (ALK) is mostly known for its oncogenic role in several human cancers. Recent evidences clearly indicate new roles of ALK and its genetic aberrations (e.g. gene rearrangements and mutations) in immune evasion, innate and cell-mediated immunity. New ALK-related immunotherapy approaches are demonstrating both preclinical and clinical promises. |
| Molecular Weight | 101.11 kDa (predicted). Due to glycosylation, the protein migrates to 115-125 kDa based on Tris-Bis PAGE result. |
| Shipping | Proteins are shipped with blue ice. |
| Storage | It is recommended to store the product under sterile conditions at -70°C or lower. Samples are stable for up to 12 months at -80°C. Please avoid multiple freeze-thaw cycles and store products in aliquots. |
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