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EGFR-IN-172
Catalog No. T213103 Copy Product Info
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EGFR-IN-172 is an EGFR inhibitor that effectively suppresses the proliferation of non-small cell lung cancer (NSCLC) cells with L858R, T790M, and C797S drug-resistant mutations. It inhibits the phosphorylation of EGFR, leading to cell cycle arrest and apoptosis. EGFR-IN-172 is suitable for NSCLC research.
EGFR-IN-172
Copy Product Info🥰Excellent
Catalog No. T213103
EGFR-IN-172 is an EGFR inhibitor that effectively suppresses the proliferation of non-small cell lung cancer (NSCLC) cells with L858R, T790M, and C797S drug-resistant mutations. It inhibits the phosphorylation of EGFR, leading to cell cycle arrest and apoptosis. EGFR-IN-172 is suitable for NSCLC research.
EGFR-IN-172
Cas No. 878416-74-1
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | EGFR-IN-172 is an EGFR inhibitor that effectively suppresses the proliferation of non-small cell lung cancer (NSCLC) cells with L858R, T790M, and C797S drug-resistant mutations. It inhibits the phosphorylation of EGFR, leading to cell cycle arrest and apoptosis. EGFR-IN-172 is suitable for NSCLC research. |
| In vitro | EGFR-IN-172 (Compound 2b) exhibits significant antiproliferative activity, with IC50 values of 5.31 μM for A549 cells (EGFR WT), 0.55 μM for PC-9 cells (EGFR T790M), 0.40 μM for H1975 cells (EGFR L858R/T790M), and 2.36 μM for Ba/F3-EGFR L858R/T790M/C797S cells. At concentrations ranging from 0.1 to 10 μM, it inhibits EGFR (pEGFR) in H1975 and Ba/F3 triple mutant cells in a concentration-dependent manner. EGFR-IN-172 (0.25-1 μM, 48 h) causes H1975 cells to arrest in the G0/G1 phase, although it does not significantly affect the cell cycle of Ba/F3 triple mutant cells. Additionally, at the same concentration range and duration, it induces apoptosis in both H1975 and Ba/F3 triple mutant cells in a concentration-dependent fashion. |
| Molecular Weight | 359.4 |
| Formula | C22H18FN3O |
| Cas No. | 878416-74-1 |
| Smiles | FC1=CC=CC(=C1)C(NC2=NC=CC(=C2)C)C=3C=CC4=CC=CN=C4C3O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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