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Autophagy inducer 7
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Catalog No. T204882Cas No. 944159-20-0
Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells.
Autophagy inducer 7
😃Good
Catalog No. T204882Cas No. 944159-20-0
Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Autophagyinducer 7 (Compound SSA) serves as an inducer of autophagy (Autophagy) and apoptosis (Apoptosis). It stimulates autophagy by inhibiting Akt/mTOR signaling and the expression of downstream proteins. Additionally, Autophagyinducer 7 suppresses DNA synthesis and causes G0-G1 cell cycle arrest, ultimately inhibiting the growth of tumor cells. |
| In vitro | Autophagy inducer 7 inhibits the growth of human lung adenocarcinoma cell lines with IC50 values of 1.95 μM (HOP-62), 4.72 μM (A549), and 3.05 μM (H1299) at 72 hours. At concentrations of 0-10 μM over 24 hours, it induces apoptosis in HOP-62, A549, and H1299 cells, but less effectively than Sulindac sulfide and Staurosporine. Additionally, Autophagy inducer 7 at 0-7.5 μM for 24 hours suppresses DNA synthesis in the same cell lines and raises the percentage of cells in the G0-G1 phase of the cell cycle. It also induces autophagy and enhances autophagic flux in A549 cells by inhibiting Akt/mTOR/p70S6k signaling. |
| Molecular Weight | 410.547 |
| Formula | C24H27FN2OS |
| Cas No. | 944159-20-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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