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NBI-74330
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Catalog No. T5644Cas No. 855527-92-3
Alias NBI74330
NBI-74330 is a high-affinity CXCR3 antagonist that inhibits the binding of CXCR3 to its ligands CXCL10 and CXCL11, reduces the formation of atherosclerotic plaques in LDL receptor-deficient mice, and decreases the migration of CD4+ T cells and macrophages to the peritoneum.
NBI-74330
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Purity: 99.37%
Catalog No. T5644Alias NBI74330Cas No. 855527-92-3
NBI-74330 is a high-affinity CXCR3 antagonist that inhibits the binding of CXCR3 to its ligands CXCL10 and CXCL11, reduces the formation of atherosclerotic plaques in LDL receptor-deficient mice, and decreases the migration of CD4+ T cells and macrophages to the peritoneum.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $56 | - | In Stock | |
| 5 mg | $135 | - | In Stock | |
| 10 mg | $226 | - | In Stock | |
| 25 mg | $397 | - | In Stock | |
| 50 mg | $773 | - | In Stock | |
| 100 mg | $1,230 | - | In Stock | |
| 200 mg | $1,650 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $179 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.37%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | NBI-74330 is a high-affinity CXCR3 antagonist that inhibits the binding of CXCR3 to its ligands CXCL10 and CXCL11, reduces the formation of atherosclerotic plaques in LDL receptor-deficient mice, and decreases the migration of CD4+ T cells and macrophages to the peritoneum. |
| Targets&IC50 | [125I]-CXCL10-CXCR3:1.5 nM (Ki, in CXCR3-CHO cell membranes), [125I]-CXCL11-CXCR3:3.2 nM (Ki, in CXCR3-CHO cell membranes) |
| In vivo | Methods: DBA/1J mice were treated with NBI-74330 (100 mg/kg) in a collagen-induced arthritis (CIA) model. Arthritis scores and histopathological changes were assessed. Flow cytometry was used to investigate the effects of NBI-74330 on Th1 (IFN-γ, TNF-α, T-bet, STAT4, Notch-3, and RANKL), Th17 (IL-21, IL-17A, STAT3, and RORγt), and Th22 (IL-22) cell expression in splenic CD4 and CXCR3 T cells. RT-PCR was used to assess mRNA levels of IFN-γ, TNF-α, T-bet, RANKL, IL-17A, RORγt, and IL-22 in knee joint tissues. ELISA was used to measure serum protein levels of IFN-γ, TNF-α, and IL-17A. Results: The severity of arthritis scores and histological severity of inflammation were significantly reduced in NBI-74330-treated CIA mice. The percentages of CD4IFN-γ, CD4TNF-α, CD4T-bet, CD4STAT4, CD4Notch-3, CXCR3IFN-γ, CXCR3TNF-α, CXCR3T-bet, CXCR3STAT4, CXCR3Notch-3, CD4RANKL, CD4IL-21, CD4IL-17A, CD4STAT3, CD4RORγt, and CD4IL-22 cells were decreased in NBI-74330-treated CIA mice. In addition, NBI-74330 treatment downregulated the mRNA levels of IFN-γ, TNF-α, T-bet, RANKL, STAT3, IL-17A, RORγt, and IL-22. [1] |
| Synonyms | NBI74330 |
| Molecular Weight | 605.58 |
| Formula | C32H27F4N5O3 |
| Cas No. | 855527-92-3 |
| Smiles | [C@@H](N(CC=1C=CC=NC1)C(CC2=CC(C(F)(F)F)=C(F)C=C2)=O)(C)C=3N(C(=O)C=4C(N3)=NC=CC4)C5=CC=C(OCC)C=C5 |
| Relative Density. | no data available |
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (132.1 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 3.3 mg/mL (5.45 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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