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PI3K/Akt/mTOR-IN-4
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Catalog No. T209582
PI3K/Akt/mTOR-IN-4 (compound 4r) is a potent inhibitor targeting PI3K/Akt/mTOR pathways and tubulin polymerization. It induces apoptosis and causes cell cycle arrest at the G2/M phase. Additionally, PI3K/Akt/mTOR-IN-4 reduces the expression of p-PI3K, p-Akt, p-mTOR, and β-tubulin.
PI3K/Akt/mTOR-IN-4
PI3K/Akt/mTOR-IN-4
😃Good
Catalog No. T209582
PI3K/Akt/mTOR-IN-4 (compound 4r) is a potent inhibitor targeting PI3K/Akt/mTOR pathways and tubulin polymerization. It induces apoptosis and causes cell cycle arrest at the G2/M phase. Additionally, PI3K/Akt/mTOR-IN-4 reduces the expression of p-PI3K, p-Akt, p-mTOR, and β-tubulin.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
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| 10 mg | Inquiry | Backorder | Backorder | |
| 50 mg | Inquiry | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | PI3K/Akt/mTOR-IN-4 (compound 4r) is a potent inhibitor targeting PI3K/Akt/mTOR pathways and tubulin polymerization. It induces apoptosis and causes cell cycle arrest at the G2/M phase. Additionally, PI3K/Akt/mTOR-IN-4 reduces the expression of p-PI3K, p-Akt, p-mTOR, and β-tubulin. |
| In vitro | PI3K/Akt/mTOR-IN-4 (compound 4r) demonstrates antiproliferative activity against SiHa, HeLa, Ca Ski, LO2, and HEK-293t cells with IC50 values of 3.38, 5.03, 7.24, 21.08, and 23.96 µM respectivelywhen used in concentrations ranging from 0 to 100 µM over 48 hours. At concentrations of 0 to 16 µM for 24 hours, PI3K/Akt/mTOR-IN-4 induces apoptosis and causes cell cycle arrest in the G2/M phase. Additionally, treatment with 4, 8, and 16 µM of this compound for 24 hours results in a dose-dependent reduction in the expression of p-PI3K, p-Akt, p-mTOR, and β-tubulin protein. |
| In vivo | PI3K/Akt/mTOR-IN-4 (0-400 μM; 0-96 h) exhibits no toxicity to zebrafish embryos. |
| Formula | C29H29FN4O3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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