ip

IP7e (isoxazolo-pyridinone 7e) is a Nurr1 activator with an EC50 value of 3.9 nM.

IP7 is a diphosphoinositol pentakisphosphate regioisomer.

RO3244794 is a selective prostacyclin (IP) receptor antagonist that can be used to study liver injury.

Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.

Treprostinil (Orenitram) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).

Treprostinil Sodium (UT-15) is a potent DP1, IP and EP2 agonist (EC50: 0.6/1.9/6.2 nM).

Treprostinil diethanolamine (UT-15C) is a potent agonist of EP2, DP1, and IP, with values of 3.6, 4.4, and 32.1 nM for EP2, DP1, and IP, respectively, and 212, 826, 2505, and 4680 nM for EP1, EP4, EP3, and FPKi, respectively. Treprostinil diethanolamine contributes to the upregulation of cAMP, maintaining vascular homeostasis and causing vasodilation in human pulmonary arteries.

Tetrahexyldecyl ascorbate (BV-OSC) is a lipophilic precursor of ascorbic acid, a more stable and permeable form of vitamin C. It is a potent anti-photo-aging and anti-hyperpigmentation antioxidant that inhibits MMP enzyme activity.

MRT-10 is a Smoothened (Smo) receptor antagonist.

1V209 (TLR7 agonist T7) is a Toll-like receptor 7 (TLR7) agonist known for its anti-tumor properties.

KAG-308 is an effective selective and orally active agonist of the EP4 receptor (Ki: 2.57 nM and EC50: 17 nM for human EP4 receptor), more selective over EP1, EP2, EP3, and IP receptor. KAG-308 suppresses colitis and promotes histological mucosal healing,

L 888607 is an effective and selective CRTH2 agonist (Ki: 0.8 nM).

CI-IP3 /PM is a cell-permeable caged inositol triphosphate that promotes the release of Ca2+ from internal storage under UV photolysis.

iP300v is a negative control for iP300w

IP6K2-IN-2 (Compound 6) is an inhibitor of IP6K2, with IC50 values of 0.58 μM, 0.86 μM, and 3.08 μM for IP6K2, IP6K1, and IP6K3, respectively. It is applicable in obesity research.

IP6K-IN-1 (compound 24) is a potent and selective inhibitor of IP6K, with an IC50 of 0.896 μM. It is applicable in research related to metabolic diseases.

iP300w (Compound 9) is an inhibitor of the histone acetyltransferase p300 (KAT3B). It is applicable in the synthesis of PROTACBT-O2C.

IP2, an immunomodulatory agent, enhances PTP (Pioneer Translation Product)-derived antigen presentation in cancer cells without exhibiting cytotoxicity. Additionally, IP2 has been shown to induce tumor growth defects in mouse models [1].

IP6K2-IN-1 (Compd 20s) acts as a selective inhibitor of IP6K2, exhibiting an IC50 value of 0.55 μM [1].

IP2015 is a monoamine reuptake inhibitor that suppresses the reuptake of dopamine, serotonin (5-HT), and norepinephrine. It enhances the release of central nervous dopamine and peripheral nitric oxide (NO), leading to NO-mediated relaxation of erectile tissue, which induces erection in rat models.

IP3RPEP6 serves as a competitive inhibitor of IP3R. Its IC50 values for IP3R1, IP3R2, and IP3R3 are 9.0 μM, 3.9 μM, and 4.3 μM, respectively. This compound does not affect ryanodine receptors and Cx43 hemichannels, and it is capable of modulating intracellular calcium signaling.

IP3RCYT is an inhibitory peptide of IP3R that can prevent cytochrome C from binding with IP3R, with an IC50 of approximately 100 nM. It regulates intracellular calcium signaling. Additionally, IP3RCYT inhibits apoptosis in HeLa and Jurkat cells treated with staurosporine or membrane-bound Fas ligand (FasL).

VS-IP1 is an inhibitory peptide that can block Viperin-mediated STAT1 degradation, thereby preventing acute heart failure (AHF) induced by Coxsackievirus B3 (CVB3).

TNP (IP3K Inhibitor) is a cell-permeable inhibitor of IP6K1 and IP3K, with IC 50 values of 0.55 μM and 10.2 μM for IP6K1 and IP3K, respectively. TNP binds to the ATP-binding sites of both enzymes [1].