Shopping Cart
Remove All
Your shopping cart is currently empty
Lipid 114
😃Good
Catalog No. TCL-01813
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. It is utilized to create lipid nanoparticles (LNPs) for delivering siRNA both in vivo and in vitro. Lipid 114 LNPs encapsulating siRNA targeting IL-1β can reduce IL-1β expression in macrophages. Additionally, these LNPs lower IL-1β expression in the liver and kidneys and alleviate liver inflammation in a mouse model of LPS-induced acute liver failure.
Lipid 114
Lipid 114
😃Good
Catalog No. TCL-01813
Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. It is utilized to create lipid nanoparticles (LNPs) for delivering siRNA both in vivo and in vitro. Lipid 114 LNPs encapsulating siRNA targeting IL-1β can reduce IL-1β expression in macrophages. Additionally, these LNPs lower IL-1β expression in the liver and kidneys and alleviate liver inflammation in a mouse model of LPS-induced acute liver failure.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
Add to Quotation
In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Lipid 114 is an ionizable cationic lipid with a pKa of approximately 6.8. It is utilized to create lipid nanoparticles (LNPs) for delivering siRNA both in vivo and in vitro. Lipid 114 LNPs encapsulating siRNA targeting IL-1β can reduce IL-1β expression in macrophages. Additionally, these LNPs lower IL-1β expression in the liver and kidneys and alleviate liver inflammation in a mouse model of LPS-induced acute liver failure. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Lipid 114 | purchase Lipid 114 | Lipid 114 cost | order Lipid 114
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.