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NF-1819

🥰Excellent
Catalog No. T28165Cas No. 1881244-28-5
Alias NF1819, NF 1819

NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.

NF-1819

NF-1819

🥰Excellent
Purity: 99.55%
Catalog No. T28165Alias NF1819, NF 1819Cas No. 1881244-28-5
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
Pack SizePriceAvailabilityQuantity
5 mg$58In Stock
10 mg$97In Stock
25 mg$198In Stock
50 mg$358In Stock
100 mgPreferentialIn Stock
1 mL x 10 mM (in DMSO)$58In Stock
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Batch Information

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Purity:99.55%
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COA HNMR LCMS

Product Introduction

Bioactivity
Description
NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
SynonymsNF1819, NF 1819
Chemical Properties
Molecular Weight463.46
FormulaC24H22FN5O4
Cas No.1881244-28-5
Smiles[H][C@@]1(N(C2CCN(CC2)C(=O)n2cncn2)C(=O)[C@]1([H])c1ccc(F)cc1)c1ccc2OCOc2c1
Relative Density.1.54 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 55 mg/mL (118.67 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.32 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1577 mL10.7884 mL21.5768 mL107.8842 mL
5 mM0.4315 mL2.1577 mL4.3154 mL21.5768 mL
10 mM0.2158 mL1.0788 mL2.1577 mL10.7884 mL
20 mM0.1079 mL0.5394 mL1.0788 mL5.3942 mL
50 mM0.0432 mL0.2158 mL0.4315 mL2.1577 mL
100 mM0.0216 mL0.1079 mL0.2158 mL1.0788 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

NF-1819MAGL
Related Tags: buy NF-1819 | purchase NF-1819 | NF-1819 cost | order NF-1819 | NF-1819 chemical structure | NF-1819 formula | NF-1819 molecular weight
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