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NF-1819

Name: NF-1819
Brand: TargetMol
SKU: T28165
Price: 358 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T28165Cas No. 1881244-28-5

Alias NF1819, NF 1819

NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.

NF-1819

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Purity: 99.55%

Catalog No. T28165Alias NF1819, NF 1819Cas No. 1881244-28-5

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$58	-	In Stock
10 mg	$97	-	In Stock
25 mg	$198	-	In Stock
50 mg	$358	-	In Stock
100 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$58	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.55%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	NF-1819 is a potent and selective irreversible MGL (β-lactam-based monoacylglycerol lipase) inhibitor. NF-1819 alleviates symptoms in a MS model in vivo and exhibits analgesic effects in an acute inflammatory pain model in vivo. NF-1819 displays high membrane permeability and brain penetrant.
Synonyms	NF1819, NF 1819

Chemical Properties

Molecular Weight	463.46
Formula	C₂₄H₂₂FN₅O₄
Cas No.	1881244-28-5
Smiles	[H][C@@]1(N(C2CCN(CC2)C(=O)n2cncn2)C(=O)[C@]1([H])c1ccc(F)cc1)c1ccc2OCOc2c1
Relative Density.	1.54 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (118.67 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1577 mL	10.7884 mL	21.5768 mL	107.8842 mL
5 mM	0.4315 mL	2.1577 mL	4.3154 mL	21.5768 mL
10 mM	0.2158 mL	1.0788 mL	2.1577 mL	10.7884 mL
20 mM	0.1079 mL	0.5394 mL	1.0788 mL	5.3942 mL
50 mM	0.0432 mL	0.2158 mL	0.4315 mL	2.1577 mL
100 mM	0.0216 mL	0.1079 mL	0.2158 mL	1.0788 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc