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Astrophloxine

Name: Astrophloxine
Brand: TargetMol
SKU: T63540
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T63540Cas No. 14696-39-0

Astrophloxine is a fluorescent imaging probe that targets antiparallel dimers and can be used to detect aggregated Aβ in brain tissue and cerebrospinal fluid samples from Alzheimer's disease (AD) mice.

Astrophloxine

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Purity: 99.89%

Catalog No. T63540Cas No. 14696-39-0

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.89%

Appearance:Solid

Color:Black

Resource Download

COA HNMR LCMS

Product Introduction

Astrophloxine AI Summary

Astrophloxine inhibits the aggregation of His-tagged human recombinant 2N4R tau protein, assessed by its ability to inhibit octadecyl sulphate-induced fibrillation using a filter trap assay, with an IC50 value of 980.0 nM. Additionally, Astrophloxine targets His-tagged PRMT1 expressed in Escherichia coli BL21(DE3) cells, demonstrating an IC50 value of 284200.0 nM as measured by scintillation counting using [14C]-S-adenosyl-L-methionine and histone H4 peptide in an 8-minute assay. It also shows dose-dependent inhibitory activity in displacing [3H]-SAM from recombinant His6-tagged PRMT1, with 60.6% inhibition at 90 µM, 42.0% inhibition at 30 µM, and 4.0% inhibition at 10 µM, indicating potential bioactivity as a PRMT1 inhibitor..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Chemical Properties

Molecular Weight	512.47
Formula	C₂₇H₃₃IN₂
Cas No.	14696-39-0
Smiles	[I-].CCN1\C(=C\C=C\C2=[N+](CC)c3ccccc3C2(C)C)C(C)(C)c2ccccc12

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (107.32 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9513 mL	9.7567 mL	19.5133 mL	97.5667 mL
5 mM	0.3903 mL	1.9513 mL	3.9027 mL	19.5133 mL
10 mM	0.1951 mL	0.9757 mL	1.9513 mL	9.7567 mL
20 mM	0.0976 mL	0.4878 mL	0.9757 mL	4.8783 mL
50 mM	0.0390 mL	0.1951 mL	0.3903 mL	1.9513 mL
100 mM	0.0195 mL	0.0976 mL	0.1951 mL	0.9757 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc