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Lipid TD5
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Catalog No. TCL-02159
Lipid TD5, an ionizable cationic lipid (pKa = 7.3), is utilized in the creation of lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. These LNPs are internalized via endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes. When administered intrathecally, LNPs containing lipid TD5 preferentially target the brain over the liver and spleen in mice.
Lipid TD5
Lipid TD5
😃Good
Catalog No. TCL-02159
Lipid TD5, an ionizable cationic lipid (pKa = 7.3), is utilized in the creation of lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. These LNPs are internalized via endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes. When administered intrathecally, LNPs containing lipid TD5 preferentially target the brain over the liver and spleen in mice.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | Lipid TD5, an ionizable cationic lipid (pKa = 7.3), is utilized in the creation of lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. These LNPs are internalized via endocytosis in a serotonin (5-HT) receptor subtype 1A-dependent manner in primary mouse astrocytes. When administered intrathecally, LNPs containing lipid TD5 preferentially target the brain over the liver and spleen in mice. |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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