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EZ-482

Name: EZ-482
Brand: TargetMol
SKU: T15265
Price: 149 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15265Cas No. 1016456-76-0

Alias EZ482

EZ-482 is an apolipoprotein (apoE) ligand that binds to the C-terminal domain of apoE3 and apoE4 through a unique N-terminal allosteric effect, useful in Alzheimer's disease research.

EZ-482

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Purity: 97.29%

Catalog No. T15265Alias EZ482Cas No. 1016456-76-0

EZ-482 is an apolipoprotein (apoE) ligand that binds to the C-terminal domain of apoE3 and apoE4 through a unique N-terminal allosteric effect, useful in Alzheimer's disease research.

Pack Size	Price	Availability	Quantity
2 mg	$149	In Stock

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Purity:97.29%

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Product Introduction

Bioactivity

Description	EZ-482 is an apolipoprotein (apoE) ligand that binds to the C-terminal domain of apoE3 and apoE4 through a unique N-terminal allosteric effect, useful in Alzheimer's disease research.
Targets&IC50	ApoE3/ApoE4:~8 μM (Ki)
In vitro	The dissociation constant of EZ-482 from apoE3 and apoE4 is about 8 μM. EZ-482 (10 or 20 μM) does not directly affect apoE binding to lipids. [1]
In vivo	In combination with anti-PD-1, EZ-482 (administered daily by oral force-feeding at a concentration of 15 mg/kg) reversed M2-EXO-induced ICB resistance in a mouse model of MC38 tumors.[2]
Synonyms	EZ482

Chemical Properties

Molecular Weight	498.94
Formula	C₂₃H₁₉ClN₄O₅S
Cas No.	1016456-76-0
Smiles	O=C(NC1=CC(=CC=C1O)S(=O)(=O)NC=2C=CC=C(Cl)C2)CC3=NN(C(=O)C=4C=CC=CC43)C
Relative Density.	1.49 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (120.25 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0042 mL	10.0212 mL	20.0425 mL	100.2125 mL
5 mM	0.4008 mL	2.0042 mL	4.0085 mL	20.0425 mL
10 mM	0.2004 mL	1.0021 mL	2.0042 mL	10.0212 mL
20 mM	0.1002 mL	0.5011 mL	1.0021 mL	5.0106 mL
50 mM	0.0401 mL	0.2004 mL	0.4008 mL	2.0042 mL
100 mM	0.0200 mL	0.1002 mL	0.2004 mL	1.0021 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc