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OD36

Name: OD36
Brand: TargetMol
SKU: T35694
Price: 48 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T35694Cas No. 1638644-62-8

Alias OD-36, OD 36

OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.

OD36

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Purity: 99.45%

Catalog No. T35694Alias OD-36, OD 36Cas No. 1638644-62-8

OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$48	-	In Stock
5 mg	$113	-	In Stock
10 mg	$173	-	In Stock
25 mg	$289	-	In Stock
50 mg	$433	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.45%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.
Targets&IC50	RIPK2:5.3 nM (IC50), ALK2 (R206H):22 nM (IC50), ALK2:47 nM (IC50), ALK2:37 nM (Kd)
In vitro	OD36 shows activity against ALK1 (KD=90 nM).[2] OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2] OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2] OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2]
In vivo	OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically neutrophils, and to a lesser extent, lymphocytes. It decreased RIPK2-specific genes, as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3]
Synonyms	OD-36, OD 36

Chemical Properties

Molecular Weight	330.77
Formula	C₁₆H₁₅ClN₄O₂
Cas No.	1638644-62-8
Smiles	Clc1cc2OCCOCCN=C3Nc4c(cnn4C=C3)-c(c1)c2
Relative Density.	1.48 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 25 mg/mL (75.58 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0232 mL	15.1162 mL	30.2325 mL	151.1624 mL
5 mM	0.6046 mL	3.0232 mL	6.0465 mL	30.2325 mL
10 mM	0.3023 mL	1.5116 mL	3.0232 mL	15.1162 mL
20 mM	0.1512 mL	0.7558 mL	1.5116 mL	7.5581 mL
50 mM	0.0605 mL	0.3023 mL	0.6046 mL	3.0232 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc