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OD36

OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.

Catalog No. T35694Cas No. 1638644-62-8

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Purity:99.89%

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COA HNMR HPLC

OD36

Catalog No. T35694Cas No. 1638644-62-8

OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.

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Pack Size	Price	Availability
1 mg	$68	In Stock
5 mg	$163	In Stock
10 mg	$247	In Stock
25 mg	$413	In Stock
50 mg	$619	In Stock
100 mg	$932	In Stock

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Product Introduction

Bioactivity

Description	OD36 is a selective and potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 inhibits ALK2 signaling and osteogenic differentiation (KD: 37 nM), and binds efficiently to the ALK2 kinase ATP pocket.
Targets&IC50	RIPK2:5.3 nM (IC50), ALK2 (R206H):22 nM (IC50), ALK2:37 nM (Kd), ALK2:47 nM (IC50)
In vitro	OD36 shows activity against ALK1 (KD=90 nM).[2] OD36 potently antagonizes mutant ALK2 signaling and osteogenic differentiation.[2] OD36 (0.1-1 μM; 24 h; KS483 cells) efficiently inhibits BMP-6 (50 ng/mL)-induced p-Smad1/5.[2] OD36 (0.5 μM) completely prevents the activation of Smad1/5 and the gene targets ID-1 and ID-3 in response to activin A in preincubated fibrodysplasia ossificans progressiva (FOP) endothelial colony-forming cells (ECFCs).[2]
In vivo	OD36 (6.25 mg/kg; i.p.; once; C57BL/6 mice, muramyl dipeptide (MDP)-induced model of peritonitis) inhibited the recruitment of inflammatory cells to the peritoneum, specifically neutrophils, and to a lesser extent, lymphocytes. It decreased RIPK2-specific genes, as well as inflammatory cytokine and chemokine gene expression. OD36 alleviates inflammation in an acute peritonitis mice model.[3]
Alias	OD 36, OD 36 hydrochloride, OD-36

Chemical Properties

Molecular Weight	330.77
Formula	C₁₆H₁₅ClN₄O₂
Cas No.	1638644-62-8

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 25 mg/mL (75.58 mM), Sonication and heating are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0232 mL	15.1162 mL	30.2325 mL	151.1624 mL
5 mM	0.6046 mL	3.0232 mL	6.0465 mL	30.2325 mL
10 mM	0.3023 mL	1.5116 mL	3.0232 mL	15.1162 mL
20 mM	0.1512 mL	0.7558 mL	1.5116 mL	7.5581 mL
50 mM	0.0605 mL	0.3023 mL	0.6046 mL	3.0232 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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