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DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $39 | In Stock | |
10 mg | $61 | In Stock | |
25 mg | $97 | In Stock | |
50 mg | $139 | In Stock | |
100 mg | $198 | In Stock | |
500 mg | $490 | In Stock | |
1 mL x 10 mM (in DMSO) | $48 | In Stock |
Description | DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA. |
In vitro | DODAP-based LNPs delivered luciferase mRNA to HEK293T cells for 24 h; luciferase expression was lower than MC3-LNPs, indicating reduced transfection efficiency[1]. |
In vivo | Mice were injected with DODAP-LNPs (0.5 mg/kg mRNA, 200 μL); after 24 h, luciferase expression was mainly in liver and spleen but lower than MC3-LNPs[1]. |
Molecular Weight | 648.05 |
Formula | C41H77NO4 |
Cas No. | 127512-29-2 |
Smiles | C(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)CN(C)C |
Storage | store at low temperature,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (123.45 mM), Sonication is recommended. Ethanol: 80 mg/mL (123.45 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
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