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DODAP

🥰Excellent
Catalog No. T38679Cas No. 127512-29-2

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

DODAP

DODAP

🥰Excellent
Purity: 98.7%
Catalog No. T38679Cas No. 127512-29-2
DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.
Pack SizePriceAvailabilityQuantity
5 mg$39 In Stock
10 mg$61 In Stock
25 mg$97 In Stock
50 mg$139 In Stock
100 mg$198 In Stock
500 mg$490 In Stock
1 mL x 10 mM (in DMSO)$48 In Stock
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Purity:98.7%
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Product Introduction

Bioactivity
Description
DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.
In vitro
DODAP-based LNPs delivered luciferase mRNA to HEK293T cells for 24 h; luciferase expression was lower than MC3-LNPs, indicating reduced transfection efficiency[1].
In vivo
Mice were injected with DODAP-LNPs (0.5 mg/kg mRNA, 200 μL); after 24 h, luciferase expression was mainly in liver and spleen but lower than MC3-LNPs[1].
Chemical Properties
Molecular Weight648.05
FormulaC41H77NO4
Cas No.127512-29-2
SmilesC(OC(CCCCCCC/C=C\CCCCCCCC)=O)(COC(CCCCCCC/C=C\CCCCCCCC)=O)CN(C)C
Storage & Solubility Information
Storagestore at low temperature,store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (123.45 mM), Sonication is recommended.
Ethanol: 80 mg/mL (123.45 mM), Sonication is recommended.
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM1.5431 mL7.7155 mL15.4309 mL77.1545 mL
5 mM0.3086 mL1.5431 mL3.0862 mL15.4309 mL
10 mM0.1543 mL0.7715 mL1.5431 mL7.7155 mL
20 mM0.0772 mL0.3858 mL0.7715 mL3.8577 mL
50 mM0.0309 mL0.1543 mL0.3086 mL1.5431 mL
100 mM0.0154 mL0.0772 mL0.1543 mL0.7715 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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