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Elgodipine

Catalog No. T68060 CAS 119413-55-7

Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun. The Elgodipine-induced inhibition was voltage-dependent. Elgodipine is a potential compound for the treatment of angina pectoris.

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Elgodipine, CAS 119413-55-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 128.00
5 mg	In stock	$ 320.00
10 mg	In stock	$ 470.00
25 mg	In stock	$ 772.00
50 mg	In stock	$ 1,080.00
100 mg	In stock	$ 1,460.00
500 mg	In stock	$ 2,920.00

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Purity: 99.51%

Purity: 98.82%

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Description	Elgodipine significantly reduced the incidence and severity of exercise-induced angina pectoris systemically and was able to inhibit vascular smooth muscle proliferation through a mechanism independent of the expression of the transcription factors c-fos and c-jun. The Elgodipine-induced inhibition was voltage-dependent. Elgodipine is a potential compound for the treatment of angina pectoris.
Targets&IC50	Ca2+ channel:0.33 µM
In vivo	Elgodipine (64 micrograms/kg; i.v.; 22 patients) significantly decreased systemic vascular resistance as well as systolic and diastolic blood pressure, while increasing cardiac output and stroke volume. Heart rate was not affected by elgodipine, either at rest or during exercise.[1]

Molecular Weight	524.58
Formula	C29H33FN2O6
CAS No.	119413-55-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 55 mg/mL (104.85 mM)

References and Literature

1. Tamargo J, et al. Cardiovascular effects of the new dihydropyridine derivative elgodipine. Arzneimittelforschung. 1991;41(9):895-900. 2. Silke B, et al. Hemodynamic effects of intravenous elgodipine in coronary artery disease during rest and exercise, and basic pharmacokinetic parameters. Cardiovasc Drugs Ther. 1996;10(5):573-580. 3. Valdivielso JM, et al. Cardiovascular effects of elgodipine and nifedipine compared in anaesthetized rats. Eur J Pharmacol. 1997;335(2-3):193-198. 4. García-Barrado MJ, et al. Effects of verapamil and elgodipine on isoprenaline-induced metabolic responses in rabbits. Eur J Pharmacol. 2001;415(1):105-115. 5. Chulia T, et al. Comparative study of elgodipine and nisoldipine on the contractile responses of various isolated blood vessels. Eur J Pharmacol. 1995;285(2):115-122. 6. Galán L, et al. Characteristics of Ca2+ channel blockade by oxodipine and elgodipine in rat cardiomyocytes. Eur J Pharmacol. 1998;357(1):93-105.

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Keywords

Elgodipine 119413-55-7 inhibitor inhibit

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