Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harboring the human P2Y2 receptor (EC50 = 240 nM) and stimulates chloride secretion in a dose-dependent manner in primary nasal epithelial cells from cystic fibrosis patients. Moreover, UTP-γ-S prompts vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM).
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Description | Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) is a hydrolysis-resistant UTP derivative and an agonist of the purinergic P2Y2 receptor. It effectively induces inositol phosphate formation in 1321N1 astrocytoma cells harboring the human P2Y2 receptor (EC50 = 240 nM) and stimulates chloride secretion in a dose-dependent manner in primary nasal epithelial cells from cystic fibrosis patients. Moreover, UTP-γ-S prompts vasoconstriction in isolated human coronary arteries (EC50 = 25.1 µM). |
Synonyms | UTP-γ-S |
Molecular Weight | 588.14 |
Formula | C9H11N2O14P3S.4Na |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Soluble
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Uridine-5'-O-(3-thiotriphosphate) sodium UTP-γ-S inhibitor inhibit