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ZB-R-55

🥰Excellent
Catalog No. T87661Cas No. 2416593-55-8
Alias ZBR-55, ZB-R55

ZB-R-55 is an orally available and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.

ZB-R-55

ZB-R-55

🥰Excellent
Purity: 98.26%
Catalog No. T87661Alias ZBR-55, ZB-R55Cas No. 2416593-55-8
ZB-R-55 is an orally available and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$333-In Stock
5 mg$987-In Stock
10 mg$1,360-In Stock
25 mg$1,980-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Purity:98.26%
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Product Introduction

Bioactivity
Description
ZB-R-55 is an orally available and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.
In vitro
ZB-R-55 exhibits 10 times greater inhibitory activity against RIPK1 compared to GSK2982772, demonstrating exceptional kinase selectivity.[1]
In vivo
In an LPS/TNF-α-induced sepsis mouse model, oral administration of ZB-R-55 (10 mg/kg) significantly alleviated hypothermia, reduced cytokine storm, and improved survival rate. [2]
SynonymsZBR-55, ZB-R55
Chemical Properties
Molecular Weight441.48
FormulaC25H23N5O3
Cas No.2416593-55-8
SmilesCN1C=2C(OC[C@H](NC(=O)C=3NC(CC4=CC=CC=C4)=NN3)C1=O)=CC=C(C#CC5CC5)C2
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (181.21 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.47 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2651 mL11.3255 mL22.6511 mL113.2554 mL
5 mM0.4530 mL2.2651 mL4.5302 mL22.6511 mL
10 mM0.2265 mL1.1326 mL2.2651 mL11.3255 mL
20 mM0.1133 mL0.5663 mL1.1326 mL5.6628 mL
50 mM0.0453 mL0.2265 mL0.4530 mL2.2651 mL
100 mM0.0227 mL0.1133 mL0.2265 mL1.1326 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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