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ZB-R-55
🥰Excellent
Catalog No. T87661Cas No. 2416593-55-8
Alias ZBR-55, ZB-R55
ZB-R-55 is an orally available and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.
ZB-R-55
🥰Excellent
Purity: 98.26%
Catalog No. T87661Alias ZBR-55, ZB-R55Cas No. 2416593-55-8
ZB-R-55 is an orally available and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $333 | In Stock | |
| 5 mg | $987 | In Stock | |
| 10 mg | $1,360 | In Stock | |
| 25 mg | $1,980 | In Stock | |
| 50 mg | $2,720 | In Stock | |
| 100 mg | $3,680 | In Stock |
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Purity:98.26%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ZB-R-55 is an orally available and highly potent bimodal RIPK1 inhibitor with excellent kinase selectivity in lps-induced sepsis models for the study of SIRS and sepsis. |
| In vitro | ZB-R-55 exhibits 10 times greater inhibitory activity against RIPK1 compared to GSK2982772, demonstrating exceptional kinase selectivity.[1] |
| In vivo | In an LPS/TNF-α-induced sepsis mouse model, oral administration of ZB-R-55 (10 mg/kg) significantly alleviated hypothermia, reduced cytokine storm, and improved survival rate. [2] |
| Alias | ZBR-55, ZB-R55 |
| Molecular Weight | 441.48 |
| Formula | C25H23N5O3 |
| Cas No. | 2416593-55-8 |
| Smiles | CN1C=2C(OC[C@H](NC(=O)C=3NC(CC4=CC=CC=C4)=NN3)C1=O)=CC=C(C#CC5CC5)C2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (181.21 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Sci Citations
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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