DSG-PEG (MW 2000)

Name: DSG-PEG (MW 2000)
Brand: TargetMol
SKU: TCL-02183
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: DSG-PEG 2000) Copy Product Info

🥰Excellent

Synonyms: DSG-PEG 2000

Catalog No. TCL-02183 Copy Product Info

🥰Excellent

DSG-PEG (MW 2000) is a polyethylene glycol-conjugated lipid (PEG-lipid) primarily used as a key excipient in the preparation of lipid nanoparticles (LNPs) and liposomes. Its distearoyl glycerol anchor provides robust membrane anchoring within lipid bilayers. In nucleic acid delivery systems, DSG-PEG (MW 2000) modulates particle size, circulation stability, and cellular interaction kinetics, serving as a critical component for optimizing mRNA delivery efficiency and tissue targeting.

DSG-PEG
(MW 2000)

Cas No. 308805-39-2

Pack Size	Price	USA Stock	Global Stock
25 mg	$41	-	In Stock
50 mg	$58	-	In Stock
100 mg	$81	-	In Stock
250 mg	$141	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Appearance:Solid

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	DSG-PEG (MW 2000) is a polyethylene glycol-conjugated lipid (PEG-lipid) primarily used as a key excipient in the preparation of lipid nanoparticles (LNPs) and liposomes. Its distearoyl glycerol anchor provides robust membrane anchoring within lipid bilayers. In nucleic acid delivery systems, DSG-PEG (MW 2000) modulates particle size, circulation stability, and cellular interaction kinetics, serving as a critical component for optimizing mRNA delivery efficiency and tissue targeting.
In vitro	DSG-PEG (MW 2000) yields larger mRNA-LNPs than DMG-PEG, favoring alveolar deposition upon inhalation. Its slow dissociation enhances protein expression (e.g., luciferase), but the stable anchoring may limit applicability for rapid intracellular delivery [1][2].
Synonyms	DSG-PEG 2000

Chemical Properties

Cas No.

308805-39-2

Storage & Solubility Information

Storage	Keep away from direct sunlight,Keep away from moisture,Store at low temperature Powder: -20°C for 3 years \| In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information	DMSO: 18 mg/mL, Sonication is recommended.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.