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DSG-PEG (MW 2000) (Synonyms: DSG-PEG 2000)
Catalog No. TCL-02183 Copy Product Info
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DSG-PEG (MW 2000) is a polyethylene glycol-conjugated lipid (PEG-lipid) primarily used as a key excipient in the preparation of lipid nanoparticles (LNPs) and liposomes. Its distearoyl glycerol anchor provides robust membrane anchoring within lipid bilayers. In nucleic acid delivery systems, DSG-PEG (MW 2000) modulates particle size, circulation stability, and cellular interaction kinetics, serving as a critical component for optimizing mRNA delivery efficiency and tissue targeting.
DSG-PEG (MW 2000)
Copy Product Info🥰Excellent
Catalog No. TCL-02183
Synonyms DSG-PEG 2000
DSG-PEG (MW 2000) is a polyethylene glycol-conjugated lipid (PEG-lipid) primarily used as a key excipient in the preparation of lipid nanoparticles (LNPs) and liposomes. Its distearoyl glycerol anchor provides robust membrane anchoring within lipid bilayers. In nucleic acid delivery systems, DSG-PEG (MW 2000) modulates particle size, circulation stability, and cellular interaction kinetics, serving as a critical component for optimizing mRNA delivery efficiency and tissue targeting.
DSG-PEG
(MW 2000)
(MW 2000)
Cas No. 308805-39-2
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 25 mg | $41 | - | In Stock | |
| 50 mg | $58 | - | In Stock | |
| 100 mg | $81 | - | In Stock | |
| 250 mg | $141 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
Storage & Solubility Information
| Description | DSG-PEG (MW 2000) is a polyethylene glycol-conjugated lipid (PEG-lipid) primarily used as a key excipient in the preparation of lipid nanoparticles (LNPs) and liposomes. Its distearoyl glycerol anchor provides robust membrane anchoring within lipid bilayers. In nucleic acid delivery systems, DSG-PEG (MW 2000) modulates particle size, circulation stability, and cellular interaction kinetics, serving as a critical component for optimizing mRNA delivery efficiency and tissue targeting. |
| In vitro | DSG-PEG (MW 2000) yields larger mRNA-LNPs than DMG-PEG, favoring alveolar deposition upon inhalation. Its slow dissociation enhances protein expression (e.g., luciferase), but the stable anchoring may limit applicability for rapid intracellular delivery [1][2]. |
| Synonyms | DSG-PEG 2000 |
| Cas No. | 308805-39-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | DMSO: 18 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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