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MMV03
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Catalog No. T204698Cas No. 375394-80-2
Alias MMV-03, MMV 03
MMV030084 is a potent PfPKG inhibitor that displays nanomolar-level activity against liver-stage Plasmodium parasites in HepG2 cells and synchronized schizont stages of both drug-sensitive and multidrug-resistant strains, selectively inhibits male gamete exflagellation, and mechanistically targets cGMP-dependent protein kinase with sub-nanomolar potency in recombinant assays, establishing MMV030084 as a valuable antimalarial lead for multistage lifecycle intervention.
MMV03
😃Good
Catalog No. T204698Alias MMV-03, MMV 03Cas No. 375394-80-2
MMV030084 is a potent PfPKG inhibitor that displays nanomolar-level activity against liver-stage Plasmodium parasites in HepG2 cells and synchronized schizont stages of both drug-sensitive and multidrug-resistant strains, selectively inhibits male gamete exflagellation, and mechanistically targets cGMP-dependent protein kinase with sub-nanomolar potency in recombinant assays, establishing MMV030084 as a valuable antimalarial lead for multistage lifecycle intervention.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MMV030084 is a potent PfPKG inhibitor that displays nanomolar-level activity against liver-stage Plasmodium parasites in HepG2 cells and synchronized schizont stages of both drug-sensitive and multidrug-resistant strains, selectively inhibits male gamete exflagellation, and mechanistically targets cGMP-dependent protein kinase with sub-nanomolar potency in recombinant assays, establishing MMV030084 as a valuable antimalarial lead for multistage lifecycle intervention. |
| In vitro | In antiparasitic assays, MMV03 inhibited the growth of Plasmodium falciparum 3D7 strain with an EC50 of 0.6 μM. Selectivity assays using human MRC-5 fibroblasts showed an EC50 > 15 μM (selectivity index > 25), indicating efficacy against the parasite at concentrations well below those causing host cell toxicity [1]. |
| Synonyms | MMV-03, MMV 03 |
| Molecular Weight | 346.41 |
| Formula | C19H14N4OS |
| Cas No. | 375394-80-2 |
| Smiles | O=C(NC=1C=NC=CC1)C2=CN(N=C2C=3SC=CC3)C=4C=CC=CC4 |
| Storage | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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