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SB-435495

Name: SB-435495
Brand: TargetMol
SKU: T75255
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T75255Cas No. 304694-39-1

Alias SB435495, SB 435495

SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.

SB-435495

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Purity: 99.07%

Catalog No. T75255Alias SB435495, SB 435495Cas No. 304694-39-1

SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$31	-	In Stock
5 mg	$74	-	In Stock
10 mg	$119	-	In Stock
25 mg	$273	-	In Stock
50 mg	$447	-	In Stock
100 mg	$708	-	In Stock
1 mL x 10 mM (in DMSO)	$116	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.07%

Appearance:Solid

Color:White

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	SB-435495 is an orally active, selective and potent Lp-PLA2 inhibitor (IC50 of 0.06 nM) for the study of autoimmune uveitis and atherosclerosis.
Targets&IC50	Lp-PLA2:0.06 nM
In vitro	SB-435495 inhibits CYP450 3A4 with an IC50 of 10 μM and a membrane permeability of 0.017 cm/h[1]; SB-435495 (5 μM; 24 h) significantly inhibits the expression of Lp-PLA2 protein and simultaneously increases oxLDL-exposed HUVECs. Medium expression levels of AMPKα and phospho-AMPKα (T172); SB-435495 (5 μM; 24-72 h) significantly increased cell viability and NO expression and significantly decreased ET-1 expression in oxLDL-exposed HUVECs[2] .
In vivo	SB-435495 (10 mg/kg; p.o.; once) inhibits plasma Lp-PLA2 in WHHL rabbit [1]. SB-435495 (10 mg/kg; i.p.; daily for 28 days) effectively inhibits blood retinal barrier (BRB) disruption in Streptozotocin diabetic Brown Norway rats [3].
Synonyms	SB435495, SB 435495

Chemical Properties

Molecular Weight	720.82
Formula	C₃₈H₄₀F₄N₆O₂S
Cas No.	304694-39-1
Smiles	O=C1N=C(SCC2=CC=C(F)C=C2)N(C=C1CC=3C=NN(C3)C)CC(=O)N(CC4=CC=C(C=C4)C=5C=CC(=CC5)C(F)(F)F)CCN(CC)CC

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (110.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3873 mL	6.9365 mL	13.8731 mL	69.3654 mL
5 mM	0.2775 mL	1.3873 mL	2.7746 mL	13.8731 mL
10 mM	0.1387 mL	0.6937 mL	1.3873 mL	6.9365 mL
20 mM	0.0694 mL	0.3468 mL	0.6937 mL	3.4683 mL
50 mM	0.0277 mL	0.1387 mL	0.2775 mL	1.3873 mL
100 mM	0.0139 mL	0.0694 mL	0.1387 mL	0.6937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc