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RI-962

Catalog No. T73493 CAS 2763831-53-2

RI-962 is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 35.0 nM. It is utilized for the investigation of nervous system disorders and inflammatory diseases [1].

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RI-962, CAS 2763831-53-2

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	RI-962 is a potent and selective inhibitor of receptor-interacting protein kinase 1 (RIPK1), exhibiting an IC50 of 35.0 nM. It is utilized for the investigation of nervous system disorders and inflammatory diseases [1].
In vitro	RI-962 exhibits a strong inhibitory activity against RIPK1, demonstrated by an IC50 of 35.0 nM [1]. Furthermore, RI-962 offers a protective effect against necroptotic cell death, with EC50 values of 10.0 nM for HT29 cells, 4.2 nM for L929 cells, 11.4 nM for J774A.1 cells, and 17.8 nM for U937 cells [1]. At concentrations ranging from 0-100 μM over 24 hours, RI-962 safeguards cells from TSZ-induced necroptosis by impeding RIPK1's kinase activity [1].
In vivo	RI-962, administered intraperitoneally (i.p.) at a dosage of 40 mg/kg once daily for 10 days, alleviates TNFα-induced systemic inflammatory response syndrome (SIRS) and mitigates inflammation in acute DSS-induced colitis [1]. The pharmacokinetic profile of RI-962 in rats, following intravenous (i.v.), intraperitoneal (i.p.), and oral (p.o.) administration at doses of 5 and 20 mg/kg, includes a half-life (T1/2) of 2.1±0.2 hours (i.v., 5 mg/kg), 1.3±0.2 hours (p.o., 20 mg/kg), and 8.5±1.6 hours (i.p., 20 mg/kg). The peak plasma concentration (Cmax) reached 12170.4±1198.5 ng/mL (i.v.), 674.2±424.7 ng/mL (p.o.), and 3603.3±693.3 ng/mL (i.p.). The area under the concentration-time curve from zero to the last observed time point (AUC 0–t) and to infinity (AUC 0–∞) showed comparable values. The volume of distribution at steady-state (Vss) was recorded for i.v. administration at 0.4±0.1 L/kg, and the mean residence time (MRT 0–∞) varied across administration routes [1].

Molecular Weight	480.56
Formula	C28H28N6O2
CAS No.	2763831-53-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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RIPK2-IN-3 ICCB-19 hydrochloride RIPK3-IN-4 Necrostatin 2 racemate RIPK1-IN-9 GSK-843 GSK963 Necroptosis-IN-1

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RI-962 2763831-53-2 Apoptosis NF-Κb RIP kinase inhibitor inhibit

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