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Lipid 5
😃Good
Catalog No. T39502Cas No. 2089251-33-0
Lipid 5, an amino lipid compound, demonstrates proficient mRNA delivery in rodent and primate models, with favorable pharmacokinetics and minimal toxicity.
Lipid 5
😃Good
Catalog No. T39502Cas No. 2089251-33-0
Lipid 5, an amino lipid compound, demonstrates proficient mRNA delivery in rodent and primate models, with favorable pharmacokinetics and minimal toxicity.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $954 | 7-10 days | 7-10 days | |
| 100 mg | $1,570 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lipid 5, an amino lipid compound, demonstrates proficient mRNA delivery in rodent and primate models, with favorable pharmacokinetics and minimal toxicity. |
| In vitro | Substituting the linoleic tail for a primary ester-containing lipid tail (Lipid 5) enhances expression and optimizes tissue clearance. Metabolite identification studies on Lipid 5 revealed that the initial metabolic step involves the hydrolysis of the primary ester[1]. |
| In vivo | The clearance of Lipid 5 and MC3 from various mouse tissues was evaluated following the administration of 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. The liver and spleen exhibited the highest concentrations of Lipid 5, albeit at significantly lower levels than those of MC3. Detection of Lipid 5 also occurred in the plasma, lung, and kidney, but not in the heart[1]. |
| Molecular Weight | 710.182 |
| Formula | C44H87NO5 |
| Cas No. | 2089251-33-0 |
| Smiles | CCCCCCCCCOC(=O)CCCCCCCN(CCO)CCCCCCCC(=O)OC(CCCCCCCC)CCCCCCCC |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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