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Lipid 5

Catalog No. T39502 CAS 2089251-33-0

Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity.

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Lipid 5, CAS 2089251-33-0

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50 mg	Inquiry	$ 954.00
100 mg	Inquiry	$ 1,570.00

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Biological Description

Chemical Properties

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Description	Lipid 5 is an amino lipid compound that demonstrates proficient mRNA delivery in rodent and primate models, displaying favorable pharmacokinetics and minimal toxicity.
In vitro	Substituting the linoleic tail for a primary ester-containing lipid tail (Lipid 5) enhances expression and optimizes tissue clearance. Metabolite identification studies on Lipid 5 revealed that the initial metabolic step involves the hydrolysis of the primary ester[1].
In vivo	The clearance of Lipid 5 and MC3 from various mouse tissues was evaluated following the administration of 0.05 mg/kg mRNA on days 1, 8, and 15 in CD-1 female mice. The liver and spleen exhibited the highest concentrations of Lipid 5, albeit at significantly lower levels than those of MC3. Detection of Lipid 5 also occurred in the plasma, lung, and kidney, but not in the heart[1].

Molecular Weight	710.182
Formula	C44H87NO5
CAS No.	2089251-33-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Staci Sabnis, et al. A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates. Mol Ther. 2018 Jun 6;26(6):1509-1519.

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Keywords

Lipid 5 2089251-33-0 inhibitor inhibit

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